Interleukin-1 receptor associated kinase

Uematsu, S., et al., Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon- alpha induction, J. Exp. Med. 201, 6, 915, 2005. 

Butler, M.R, Hanly, J. A., Moynagh, RN. Kinase-active interleukin-1 receptor-associated kinases promote polyubiquitination and degradation of the Pellino family direct evidence for PELLINO proteins being ubiquitin-protein isopeptide ligases. 1 Biol Chem 282 (2007) 29729-29737. 

Su, J., Zhang, T., Tyson, J., Li, L. The Interleukin-1 Receptor-Associated Kinase M Selectively Inhibits the Alternative, Instead of the Classical NFkappaB Pathway. J Innate Immun 1 (2009) 164-174. 

Adib-Conquy, M., and Cavaillon, J. M. Gamma interferon and granulocyte/monocyte colony-stimulating factor prevent endotoxin tolerance in human monocytes by promoting interleukin-1 receptor-associated kinase expression and its association to MyD88 and not by modulating TLR4 expression. J Biol Chem 277 (2002) 27927-27934. 

Li, L., Cousart, S., Hu, J., and McCall, C. E. Characterization of Interleukin-1 Receptor-associated Kinase in Normal and Endotoxin-tolerant Cells. J Biol Chem 275 (2000) 23340-23345. 

Yamin, T. T., and Miller, D. K. The interleukin-1 receptor-associated kinase is degraded by proteasomes following its phosphorylation. J Biol Chem 272 (1997) 21540-21547. 

Emonts M, Hazelzet JA, de Groot R, Hermans PW 2003 Host genetic determinants of Neisseria meningitidis infections. Lancet Infect Dis 3 565—577 Enders A, Pannicke U, Berner R et al 2004 Two siblings with lethal pneumococcal meningitis in a family with a mutation in Interleukin-1 receptor-associated kinase 4. J Pediatr 145 698-700... 

This receptor family mediates the effects of interleukin 1, a major proinflammatory cytokine, and interleukin 18, and includes TLR receptors of macrophages like TLR2 which recognize peptigoglycans of gram-positive bacteria. These receptors are coupled to the cytosohc serine/threonine kinase IRAK (interleukin receptor-associated kinase). Following signals include the activation of transcription factors like NFk,B, or others via MAP kinases. 

Jurrmann N, Brigelius-Flohe R, Bol GF. 2005. Curcumin blocks interleukin-1 (IL-1) signaling by inhibiting the recruitment of the IL-1 receptor-associated kinase IRAK in murine thymoma EL-4 cells. J Nutr 135 1859-1864. 

Rao, N., Nguyen, S., Ngo, K., Fung-Leung, W.P. A novel splice variant of interleukin-1 receptor (IL-lR)-associated kinase 1 plays a negative regulatory role in Toll/IL-lR-induced inflammatory signaling. Mol Cell Biol 25 (2005) 6521-6532. 

Akama KT, Van Eldik LJ (2000) Beta-amyloid stimulation of inducible nitric-oxide synthase in astrocytes is interleukin-Ibeta- and tumor necrosis factor-alpha (TNFalpha)-dependent, and involves a TNFalpha receptor-associated factor- and NFkappaB-inducing kinase-dependent signaling mechanism. J Biol Chem 275 7918-7924... 

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