Ionic phase organic synthesis

Dabiri M, Salehi P, Baghbanzadeh M, Shakouri M, Otokesh S, Ekrami T, Doosti R (2007) Efficient and eco-friendly synthesis of dihydropyrimidinones, bis(indolyl) methanes, and N-alkyl and N-arylimides in ionic liquids. J Iran Chem Soc 4 393 01 Legeay JC, Eynde JJV, Bazureau JP (2008) Ionic liquid phase organic synthesis (loLiPOS) methodology applied to the preparation of new 3,4-dihydropyrimidine-2(lH)-ones bearing bioisostere group in N-3 position. Tetrahedron 64 5328-5335... 

Fraga-Dubreuil, J., Famelart, M.-H. and Bazureau, J.P., Ecofriendly fast synthesis of hydrophylic poly(ethyleneglycol)-ionic liquid matrices for liquid-phase organic synthesis, Org. Proc. Res. Dev., 2002,... 

A microwave dielectric heating assisted TSIL phase synthesis [45] of 1,4-dihydropyridines, 3,4-dihydropyrimidin-2(lH)-ones, pyridines and polyhydroquinolines using a TSIL as a soluble support was described. The efficiency of the ionic liquid phase organic synthesis (loLiPOS) methodology was demonstrated by using a one-pot three-component condensation. The stmcture of the intermediates... 

Advances in liquid-phase organic synthesis using functional ionic liquid as supports 07CJO1188. 

In addition, Bazureau et al. [250] also report the solvent-free synthesis of N-3 functionalized 3,4-dihydropy rimidin-2-(lH)-ones (DHPMs) 159 following an "ionic liquid-phase organic synthesis" (loLiPOS) protocol based on Biginelli condensation (Scheme 85). The tactic involves the attachment of 3,4-DHPM 155 on the ILP-bound acetoacetates in the first step followed by functionalization with 1,2,4-oxadiazole using aliphatic carboxylic anhydrides. 

H. Hakkou, J.J.E. Vanden, J. Hamelina, J.P Bazureau, Ionic liquid phase organic synthesis (loLiPOS) methodology applied to the three component preparation of 2-thioxo tetrahydropyrimidin-4-(lH)-ones rmder microwave dielectric heating. Tetrahedron 60 (2004) 3745-3753. 

Catalysis at interfaces between two immiscible liquid media is a rather wide topic extensively studied in various fields such as organic synthesis, bioenergetics, and environmental chemistry. One of the most common catalytic processes discussed in the literature involves the transfer of a reactant from one phase to another assisted by ionic species referred to as phase-transfer catalyst (PTC). It is generally assumed that the reaction process proceeds via formation of an ion-pair complex between the reactant and the catalyst, allowing the former to transfer to the adjacent phase in order to carry out a reaction homogeneously [179]. However, detailed comparisons between interfacial processes taking place at externally biased and open-circuit junctions have produced new insights into the role of PTC [86,180]. 

The previous section discussed the structure at the junction of two phases, the one a solid electron conductor, the other an ionic solution. Why is this important Knowledge of the structure of the interface, the distribution of particles in this region, and the variation of the electric potential in the double layer, permits one to control reactions occurring in this region. Control of these reactions is important because they are the foundation stones of important mechanisms linked to the understanding of industrial processes and problems, such as deposition and dissolution of metals, corrosion, electrocatalysis, film formation, and electro-organic synthesis. 

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