Ion cyclotron resonance mass spectrometry ICR-MS

Basic investigations in mass spectrometry39,40 continue to influence instrumental developments. The first application in ion cyclotron resonance mass spectrometry (ICR-MS) was described by Sommer, Thomas and Hippie in 1949.41 Free radicals were also mass spectrometrically studied by... 

GIBMS = guided ion beam mass spectrometry HPMS = high pressure mass spectrometry ICR = ion cyclotron resonance mass spectrometry KC-MS = Knudsen cell-mass spectrometry. cData at 298 K. 

Fourier transform mass spectrometry (FTMS) offers the highest mass resolution and mass measurement accuracy of all mass analyzers. FTMS, also referred to as Fourier transform ion cyclotron resonance mass spectrometry (FTICR MS), can be adapted to a wide variety of ion sources and ion dissociation methods.The fundamental behavior of ions in FTMS instmments is based on the principle of ion cyclotron resonance (ICR), conceived and developed by E. O. Lawrence in the 1930s to build ion accelerators for nuclear physics experiments. ICR was first implemented in mass spectrometry in an instrument called the omegatron, developed by scientists at the National Bureau of Standards in the 1950s. Advances such as the application of Fourier transform methods to ICR spectrometry and the trapped analyzer cell resulted in the development of a powerful analytical instmment. 

B. Asamoto (ed.), FT-ICR/MS Applications of Fourier Transform Ion Cyclotron Resonance Mass Spectrometry, VCH Publishers, New York, NY (1991). 

Attempts have been made to observe and experimentally determine the structure of CH5+ in the gas phase and study it in the condensed state using IR spectroscopy,764 765 pulse electron-beam mass spectrometry,766 and Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS).767 However, an unambiguous structure determination was unsuccessful. Retardation of the degenerate rearrangement was achieved by trapping the ion in clusters with H2, CH4, Ar, or N2. 

Kujawinski, E. B., Hatcher, P. G., and Freitas, M. A. (2002). High-resolution Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) of humic and fulvic acids Improvements and comparisons. Anal. Chem. 74,413 119. 

Technological advances of ion-trap mass spectrometers are the ultrahigh-resolution Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) and the recently released technique, the Orbitrap Fourier transform mass spectrometry (Hu et al., 2005), which enable the determination of molecular formulae with a high mass resolution and mass accuracy in mixtures. Today these ion-trap mass spectrometers are most frequently coupled with atmospheric pressure ionization (API) techniques such as electrospray ionization (ESI) (e.g., Fievre et al., 1997 Qian et al., 2001 Kujawinski et al., 2002 Llewelyn et al., 2002 Stenson et al., 2002,2003 Fard et al., 2003) or matrix-assisted laser desorption/ionization (MALDI) (e.g., Solouki et al.,... 

The MALDI-Fourier Transform Ion Cyclotron Resonance Mass Spectrometry (MALDI-FT-ICR-MS) and MALDI-Quadrupole-Ion-trap-TOF Mass Spectrometry (MALDI-QIT-TOF-MS) can be used on IMS. The FT-ICR-MS could provide the high resolution, expansive mass range and high sensitivity imaging MS data and good for determining the elemental composition of small molecules [60],... 

The quadrupole ion trap is seen as a compact and less expensive alternative to FT-ICR mass spectrometers employed for gas-phase metal ion chemical and mass analysis [28,29]. Although lacking the high mass resolving powers available in Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR-MS), the quadrupole ion trap has been investigated by using nonselective and resonance-selective ionization of ablated metal samples. 

FT-ICR-MS Fourier transform ion cyclotron resonance mass spectrometry FWHM Full width at half maximum... 

The present results demonstrate the utility of electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry (ESI FT-ICR MS) for analysis of hydrogen/deuterium exchange to determine the number of... 

The gas-phase reactions of lanthanide (Ln+ = La+-Lu+, except Pm+) cations with iron pentacarbonyl, Fe(CO)s, and with ferrocene, Cp2Fe, have been studied by Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR/ MS). In the case of Fe(GO)s, the observed primary products were of the type LnFe(CO)x+ (Ln = La, Ce, Pr, Nd, Gd, Tb v = 3 Ln = Ho, Er, Lu x = 3 and 4 Ln = Sm, Eu, Dy, Tm, Yb x = 4), and evidence was obtained for the presence of direct Ln-Fe bonds in these species. With Cp2Fe the majority of the Ln+ cations reacted by metal exchange, yielding Ln bis(cyclopentadienyl) ions Cp2Ln+, while the less reactive Ln+ cations formed the adduct ions LnFeCp2+.851... 

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