Iodopropionic acid

HydracryUc Acid, CH2OH.CH2.COOH, 0-hydroxy-propionic acid, is isomeric with lactic acid. It can be prepared heating by 0-iodopropionic acid with water —... 

By the action of nitrous acid in hydrochloric acid solution on bromo-phenylcystine, prepared by Baumann s method, chlorobromophenyl-thiopropionic acid was obtained, which, on reduction, gave bromophenyl-thiolactic acid. This was identical with the substance prepared from j8-iodopropionic acid and sodium bromophenylmercaptan —... 

Preparation 315.—jS-Iodopropionic Acid [Z-Iodo-pentan acid],... 

From the reaction of 3-iodopropionic acid and 2-aminopyridines, Krishnan obtained the pyridopyrimidines (142). From 2-amino-6-methyl-... 

Adipic acid has been prepared by the following methods the action of silver1 or copper 2 on /3-iodopropionic acid the reduction of mucic add with phosphorus and iodine 3 the electrolysis of the potassium or sodium salts of monoethyl succinate 4 the condensation of ethylene chloride or bromide with malonic ester or cyanoacetic ester and subsequent hydrolysis 5 the oxidation of certain fractions of Baku petroleum 6 the oxidation of cyclohexanol or cyclohexanone with nitric acid 7 or potassium permanganate.8... 

The acrylic acid is now dissolved in the minimum quantity of water, and the calculated amount of concentrated hydrogen iodide solution gradually added, shaking well after each addition. When all has been added, the mixture is warmed on the water-bath for one hour and then evaporated to crystallisation the resulting /3-iodopropionic acid melts at 82°. 

Alkoxy- or 2-aryloxy-5,6-dihydro-TAs 106 may be obtained in two ways—from 3-iodopropionic acid (1891CB3848) and from acryloyl halides (89USP4839356—by the action of a thiocarbamate (Scheme 35). 

Figure 9.8. The 60-MHz H spectrum of 3-iodopropionic acid. Sadtler Research Laboratories. Division of Bio-Rad Laboratories, Inc. (1973).

NAD binding at pH 7.4 (156) and positive cooperativity at pH 8.5 (155), in agreement with earlier studies (101). Eisele and Wallenfels (119) have also provided support for the concerted model with studies on the rate of stereoselective inhibition of the yeast enzyme by the antipodes of a-iodopropionic acid and a-iodopropionamide at varying NAD concentrations. In similar experiments the muscle enzyme showed negative cooperativity. 

Mr. Wislicenus has, in fact, recently announced that he has found an active acid in meat. This acid does not have, as has been believed, the constitution of the ethylene lactic acid but it is according to this author a physical isomer of the ordinary lactic acid. Indeed one cannot see that the ethylene lactic acid can be active, for the carbons of the radical are each one combined with two atoms of hydrogen, as the formula shows CH2 OH CH2 GOOH. We see also that the propylene glycol and the iodopropionic acid which are derived from the active lactic acid will preserve the rotatory power, but it will not be the same with the glycerine which one can derive from it, for in that case the central carbon atom is united with the two equal radicals CH2 OH,... 

The reaction of 5-biological implications discussed. "... 

Amido-propionic acids — Alanins — CiHiNOi — 89.— Two are known, isomeric with sarcosin and with lactamid. One, a Alanin,. CH,-CH (NH,)-COOH, is formed by the reduction of a nitroso-propionic acid by Sn-j-HCl. The other, j3 Alanin, CHiNHi—CH> —COOH, whose constitution is similar to that of glycocol, is formed either by the reduction of /J nitrosopropionic acid, or by the action of 13 iodopropionic acid on ammonia. either exists, so far as known at present, in nature. 

It is formed along with tyrosin by the decomposition of nitro-genized animal and vegetable substances, by heating with strong-alkalies or dilute acids and is one of the products of putrefaction. It is best obtained by the action of hot dilute HjSOt on bone shavings. It has also been formed synthetically by the action of NHs upon bromocaproic acid, in the same way that alanin is formed from iodopropionic acid (see above). 

Iodopropionic Acid can be made from acrylic acid and hydriodic acid,—... 

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