Iodoform Subject

A correlation of voacoline with voacarpine was carried out on a small scale, with thin-layer chromatography an important tool for following the reactions. Voacoline was refluxed in benzene with potassium tertiary butylate to yield a complex mixture containing IX (positive iodoform reaction) which was esterified and subjected to a Wolf-Kishner reaction. From the products of this reaction a- and jS-dihydrodehydroxymethyl-voachalotine (X C-20 epimers) were recognized by thin-layer chromatography. 

Fluorodibromo- [19] and fluorodiiodomethane [20] each react to form a fluorohalocarbene. Chlorodiiodomethane and triiodomethane (iodoform) have likewise been subjected to phase transfer conditions and have yielded the expected car-benes [21 ]. On the other hand, chlorodifluoromethane (Freon 22) did not yield the desired difluorocarbene and it appears that no attempt to prepare either chlorobromo-... 

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