Iodine sufficient group

Fenzi studied the prevalence of thyroid antibodies in a moderate endemic goiter area of Italy (Fenzi et ai, 1986). Schoolchildren n = 142) and their parents n = 159) were included. The overall frequency of Mic-Ab and Tg-Ab in the adult population was 14.4%, which was significantly higher than that in the sex- and age-matched control group living in an iodine-sufficient area. It was observed that antibodies were more common in subjects with goiter compared to subjects without goiter. 

The study group included 16 children born to 16 healthy mothers living in the moderately iodine deficient area (ID area), and 11 age-matched control children bom to 11 women from a marginally iodine-sufficient area (IS area). The characteristics of both areas when the children were conceived (1990-1992), and at the time of the study, are reported in Table 68.2. 

It was mentioned earlier (Sec. 8.6) that for iodo-de-diazoniation no catalyst is necessary because the redox potential of the iodide ion (E° = 1.3 V) is sufficient for an electron transfer to the arenediazonium ion. The reaction was actually observed by Griess (1864 c). Four iodo-de-diazoniation procedures are described in Organic Syntheses. For the syntheses of iodobenzene and 4-iodophenol (Lucas and Kennedy, 1943, and Daines and Eberly, 1943, respectively) KI is used in equimolar quantity and in 1.2 molar excess. However, for 2-bromoiodobenzene and for 1,3,4-triiodo-5-nitrobenzene (replacement of a diazonio group in the 4-position by iodine), up to... 

Dy-EOB-DTPA). The second group is represented by liposomes with different extracellular iodinated contrast agents that are encapsulated and by PFOB. Efficacy does not seem to be an issue for these agents. The future will show whether their safety will be sufficient for further development. 

This method may be used in the context of repeated dose treatment, on satellite groups of rats which show changes in thyroid uptake of labelled iodine. It may be sufficient to determine radio-iodine uptake in controls and in the high-dose group. 

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