Introduction of reactive groups

One feature which is peculiar to reactions on supports concerns the various effects of adjacent or local groups. These can for example modify the reactivity of other groups (e.g. the pKa of carboxylic acids is a function of the overall degree of ionisation of the array of groups) [42] or they may facilitate unwanted side-reactions. For example, in attaching a symmetrical a,co-difunctional molecule to a site on a support once one end of 

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Introduction of reactive groups in nucleic acid by transamination... 

Introduction of reactive groups on the phenyl substituents of poly(phenyl/alkylsilane)s can be accomplished. These can be further utilized for anchoring other chemical entities of choice. 

By the introduction of reactive groups in NAD, analogs are obtained that complex with the enzyme at its active center and then form covalent bonds with corresponding amino acid residues in a manner similar to NAD itself. For this purpose, halogen ketones, azo groups, and diazo ketones were found to be suitable reactive groups. ... 

Phase I metabolism is metabolic activation, leading to the introduction of reactive groups. Many such reactions involve hydroxylation catalysed by cytochromes of the P 5Q family. 

Using concepts previously discussed in this chapter it is possible to produce new, previously unknown copolymers, with monomers that are easily accessible commercially. Terpolymers with previously unknown properties may be created by terpolymerization of donor-acceptor pairs with neutral monomers, and introduction of reactive groups on these polymers has practical significance. It is obvious that possible applications also include using selected systems or initiators for free-radical, photoreactive, and ionic polymerizations as well as the generation and crosslinking of reactive oligomeric materials. These few mentioned possibilities clearly show that a new field of polymer synthesis reactions is now open, which is of both theoretical and practical interest. 

Versatile functional aliphatic polyesters have been prepared by copolymerization with the above mentioned functional monomers. The introduction of reactive groups along the chains is highly desirable for fine tuning the polymer properties, such as chemical reactivity, biocompatibility, biodegradability and... 

An additional increase in grafting density for the attachment from the melt can be achieved when the PGMA anchoring layer is used for the introduction of reactive group on a substrate surface. Attachment... 

Wooley and coworkers utilized click chemistry to prepare block copolymer micelles and shell cross-linked nanoparticles (SCKs) presenting click-reactive functional groups on their surfaces [144,145]. Moreover, they presented the preparation of well-defined core cross-linked polymeric nanoparticles, utilizing multifunctional dendritic cross-linkers that allow for the effective stabilization of supramolecular polymer assemblies and the simultaneous introduction of reactive groups within the core domain [146]. 

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