Urticaria intravenous immunoglobulin

Skin reactions to intravenous immunoglobulin are rare (52,93-95). Other reported reactions include urticaria, maculopapular rashes, petechiae, eczema, and erythema multiforme (31,96). 

Infusion of intravenous immunoglobulin 0.14 g/kg in 17 patients with autoimmune diseases, in whom circulating immunoglobulins had been depleted, was associated with a high incidence of serious adverse effects (94). Treatment was terminated in four patients because of adverse effects, including urticaria, severe hypotension, arthralgia, and chest discomfort. 

Other adverse reactions include lightheadedness [40 ], fainting [39 ], and self-limiting aseptic meningitis, which occurs occasionally 48-72 hours after the first dose [30 ]. One patient with chronic spontaneous urticaria developed symptoms of aseptic meningitis on day 3 of a 5-day cycle of intravenous immunoglobulin the immunoglobulin was withdrawn and the urticaria returned to baseline in 2 weeks [56 ]. 

Skin Cutaneous reactions that are associated with intravenous immunoglobulin include erythema at the injection site, rashes, urticaria [40 ], and eczema [43 ]. 

Mitzel-Kaoukhov H, Staubach P, Muller-Brenne T. Effect of high-dose intravenous immunoglobulin treatment in therapy-resistant chronic spontaneous urticaria. Ann Allergy Asthma Tmmnnol 2010 104(3) 253-8. 

Skin Cutaneous reactions associated with intravenous immunoglobulin are uncommon, but include pruritus, non-specific eruptions, erythema, urticaria, eczema, pompholyx, pete-chiae, and skin hemorrhage [53, 54 , 55 , 57 , 59 ]. 

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