Intravenous bolus administration of drugs summary

Blood samples must also be collected during the early period following the administration of a drug. 

Plasma or serum samples are analyzed by a suitable method to obtain plasma (Cp) or serum (Cs) concentrations at various times. 

Why collect blood samples up to 4.32 elimination half lives This is because it always takes 4.32 X fi/2 of a drug for 95% of the drug to disappear from the body (blood). 

In this example, since 1 h is equal to one half life (ti/z) of the drug, 4.32 h is equal to 4.32 half lives. 

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