Intracellular signaling potassium currents

CBi and CB2 seem to couple to inhibitory Gj and/or G0 proteins. CBi receptors are known to effect adenylate cyclase, a variety of potassium and calcium currents, and the mitogen-activated protein kinase pathway. CBi receptors have been shown to activate at least six subtypes of Gj and G0 proteins, supporting reports that they effect a wide variety of intracellular signaling systems. In contrast to CB receptors, CB2 receptors do not seem to effect ion currents directly (Breivogel et al., 2001). 

Hidalgo, J. et al.. Pacific ciguatoxin-lb effect over Na and K currents, inositol 1,4,5-triphosphate content and intracellular Ca signals in cultured rat myotubes, Br. J. Pharmacol, 137, 1055, 2002. Birinyi-Strachan, L.C. et al.. Block of voltage-gated potassium channels by Pacific ciguatoxin-1 contributes to increased neuronal excitability in rat sensory neurons, Toxicol. Appl. Pharmacol, 204, 175, 2005. 

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