Interstitial nephritis beta-lactams

Beta-lactam antibiotics (pencillins, cephalosporins, and carbapenems) are excreted by the kidneys and hence the kidneys are targets of toxicity. These drugs can cause interstitial nephritis, tubular necrosis, and allergic angitis. Beta-lactams behave like haptens which are then... [Pg.565]

With other beta-lactams, mainly penicillin G, acute interstitial nephritis is rare, but it can follow the same pattern (188). [Pg.485]

The underlying mechanism of a series of clinical entities associated with beta-lactams, such as maculopapular rash, drug fever, eosinophilia, serum sickness-like disease, vesicular and bullous skin reactions, erythema nodosum, and acute interstitial nephritis, is suspected to be immunological but is still largely unknown. [Pg.486]

Antimicrobials Aminoglycosides, beta-lactams, vancomycin Acute interstitial nephritis, tubular cell toxicity, glomerulonephritis... [Pg.326]