Internal aplasia

Gill MJ, Ratliff DA, Harding LK. Hypoglycemic coma, jaundice, and pure RBC aplasia following chlorpropamide therapy. Arch Intern Med 1980 140(5) 714-5. 

Creemers GJ, van Boven WP, Lowenberg B, van der Heul C. Azathioprine-associated pure red cell aplasia. J Intern Med 1993 233(l) 85-7. 

Giannone L, Kugler JW, Krantz SB. Pure red cell aplasia associated with administration of sustained-release procainamide. Arch Intern Med 1987 147(6) 1179-80. 

The major toxicological manifestation of chronic benzene exposure in humans is bone marrow depression. Clinical manifestations include anemia, leuco-penia, and thrombocytopenia. In severe cases, bone marrow aplasia develops. Later stages of toxicity are manifested by pancytopenia and aplastic anemia. Death may result from aplastic anemia or from leukemia. The US Environmental Protection Agency (EPA) and International Agency for Research on Cancer classify benzene as a known human carcinogen. 

Yamamoto T, Uchiyama T, Takahashi H, Himiiro K, Kanai K, Kuwabara S. B cell aplasia and hypogammaglobulinemia after carbamazepine treatment. Intern Med 2010 49(7) 707-8. 

Abrams SM, Degnan TJ, Vinciguerra V (1980) Marrow aplasia following topical application of chloramphenicol eye ointment. Arch Intern Med 140 576-577 Adriani J, Zepernick R (1964) Clinical effectiveness of drugs used for topical anesthesia. JAMA 118 711 Albert T, Lewis N, Warpeha R (1982) Late pulmonary complications with use of mafenide acetate. J Burn Care Rehabil 3... 

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