Intermedine

Many herbal teas, comfrey Pyrrolizidine alkaloids, including intermedine, lycopsamine, and symphytine... 

Pyrrohzidine alkaloids Pyrrohzidine Acetyl- lycopsamine Acetyl-intermedine Europine Homospermidine namine Indicine-A-oxide Meteloidine Retronecine... 

Boraginaceae Heliotropium indicum Cynoglossum spp. Symphytum officinale Indicine-A-oxide Indicine-A-oxide Acetyl-intermedine Acetyl-lycopsamine... 

Later, from the eggs of S. intermedins, two sialoglycolipids were isolated that had the same type of structure as the sialoglycolipid from the gonads, but they contained only N-glycolylneuraminic acid, and, in one of them, this acid was sulfated.289,290... 

Replacing T. intermedins with E. coli as a source for PheDH, 197 kg of (S)-allysine ethylene acetal product was produced in three batches with an average yield of 91% mol/mol and the e.e. was > 98%. 

N. K. Kochetkov, I. G. Zhukova, G. P. Smirnova, and I. S. Glukhoded, Isolation and characterization of a sialoglycolipid from the sea urchin Strongylocentrotus intermedins, Biochim. Biophys. Acta, 326 (1973) 74-83. 

Russian comfrey (Symphytum x uplandicum Nyman) is widely recommended as a medicinal herb and an item of human diet. A previous investigation of this species led to the isolation of three alkaloids which were not fully characterized (cf. Vol. 7, p. 57). Culvenor and co-workers have separated eight pyrrolizidine alkaloids from the leaves of this perennial plant by counter-current distribution.21 The known alkaloids echimidine (51), symphytine (52), lycopsamine (53), and intermedine (54) were present. In addition, four new alkaloids, i.e. 7-acetyl-lycopsamine (55), 7-acetylintermedine (56), symlandine (57), and uplandicine (58), were characterized by spectroscopic methods, and by hydrolysis. The total alkaloidal extract caused chronic hepatotoxic effects in rats, and the authors... 

Echimidine Symphytine Lycopsamine Intermedine 7-Acetyl-lycopsamine 7 - Acetylintermedine Symlandine Uplandicine... 

Formate dehydrogenase has been reported to have a pH optimum of 7.5-8.5 [25], The pH optimum for the reductive amination of (5) by an extract of T. intermedins was found to be about 8.7. Reductive amination reactions were carried out at pH 8.0. A summary of laboratory-scale batches is shown in Table 2. The time course for a representative batch showing conversion of ketoacid (5) to amino acid (4) is presented in Figure 5 using E. coli/C. boidinii heat-dried cells. 

RL Hanson, JM Howell, TL LaPorte, MJ Donovan, DL Cazzulino, V Zannella, MA Montana, VB Nanduri, SR Schwarz, RF Eiring, SC Durand, JM Wasylyk, WL Parker, LJ Szarka, RN Patel. Synthesis of allysine ethylene acetal using phenylalanine dehydrogenase from Thermoactinomyces intermedins. Enzyme Microbial Technol 26 348-358, 1999. 

Eupatorieae Tribe.—Nine Eupatorium species that are found in the U.S.A. have been screened for pyrrolizidine alkaloids by Herz et al.2i Intermedine (42) (crystalline for the first time) and echinatine were isolated from Conoclidium coelestinum (L.) DC. (syn. Eupatorium coelestinum L.). Intermedine (42) and lycopsamine (41) were present in E. compositifolium Walt. These diastereoisomeric diols were separated as their borate complexes.29 Rinderine and 7-angelyl-heliotridine (43) were isolated from E. altissimum L.28... 

Continuous Citrobacter intermedins 37 Glucose 0.220 121.4 NA 20.6 Brosseau and Zajic (1982)... 

Celtis sp., indet.—1 Gastropoda indet.—2 Bufo sp. indet.—1 Ophisaurus intermedins Bolkay—1 Ophidia indet.—ca. 3,400 Talpa fossilis Pet6nyi—1 Sorex runtonensis Hinton—16 Beremendia fissidens (Petenyi)—20 Spalax advenus Kretzoi—1 Apodemus cf. syhaticus (L.)... 

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