Interleukin STAT activation

Alas S, Bonavida B. Rituximab inactivates signal transducer and activation of transcription 3 (STATS) activity in B-non-Hodgkin s lymphoma through inhibition of the interleukin 10 autocrine/paracrine loop and results in down-regulation of Bcl-2 and sensitization to cytotoxic drugs. Cancer Res 2001 61 5137-5144. 

Demoulin JB, Uyttenliove C, Van Roost E, et al. A single tyrosine of the interleukin-9 (IL-9) receptor is required for STAT activation, antiapoptotic activity, and growth regulation by IL-9, Mol CeU Biol 1996 16 4710-6. 

Wegenka, U.M., Liitticken, C., Buschmann, J., Yuan, J., Lott-speich, F., Muller-Esterl, W., Schindler, C., Roeb, E., Heinrich, P.C. and Horn, F. (1994) The interleukin-6-activated acute-phase response factor is antigenically and functionally related to members of the signal transducer and activator of transcription (STAT) family. Mol. Cell. Biol. 14 3186-3196. 

Cytokine receptors that couple to the JAK-STAT Pathway decode the signaling though hematopoietic cytokines (erythropoietin, thrombopoietin, colony-stimulating factors), prolactin, growth hormone, the a-, (3- and y- interferons, and a number of immunomodulatory interleukins [3], They form homodimetic or heterodimeric receptor complexes, which after ligandbinding recruit and activate isotypes of Janus kinases (JAKs). Activated JAKs in turn... 

Cassatella MA, Gasperini S, Bovolenta C, Calzetti F, Vollebregt M, Scapini P, Marchi M, Suzuki R, Suzuki A, Yoshimura A Interleukin-10 (lL-10) selectively enhances C1S3/SOCS3 mRNA expression in human neutrophils Evidence for an IL-lO-induced pathway that is independent of STAT protein activation. Blood 1999 94 2880-2889. 

Jacohson, NG, Szabo SJ, Weber-Nordt RM, Zhong Z, Schreiber RD, Darnell JE Jr, Murphy KM. Interleukin 12 signahng in T helper type 1 (Thl) cells involves t5Tosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4. J Exp Med 1995 181 1755-1762. 

IFN, interferon IL, interleukin IRF, interferon regulatory factor RA, retinoic acid STAT, signal transducing activator of transcription. 

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