Interferon alfa interstitial pneumonia

Respiratory Pegylated interferon alfa combined with ribavirin is currently the standard treatment for hepatitis C virus infection, and ursodeoxychoUc acid is used as a supportive treatment in patients who are non-responders or develop severe adverse reactions. Interstitial pneumonia has been attributed to this [110 ]. 

A 62-year-old Japanese man with a renal cell carcinoma and multiple metastases, who had had inactive idiopathic interstitial pneumonia for 5 years without treatment, was given three intramuscular injections of standard-dose interferon-alfa and had an acute exacerbation of the interstitial pneumonia [36 ]. 

Puimonary disorders Dyspnea, pulmonary infiltrates, pneumonia, bronchiolitis obliterans, interstitial pneumonitis, and sarcoidosis, some resulting in respiratory failure and/or patient deaths, may be induced or aggravated by peginterferon alfa-2a or alpha interferon therapy. 

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