Interagency Coordinating Committee on the Validation of Alternative Methods

At the same time. Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) evaluated FETAX methodology based on the inter-laboratory studies and published a review document in 2000 (5). The expert panel concluded that FETAX was not sufficiently validated for regulatory use due to the intra- and inter-laboratory variability (6). Nonetheless, the assay was developed in our laboratory for use as a predictive screening assay. 

The National Institute of Environmental Health Sciences was directed by Public Law 103-43 to develop and validate alternative methods for acute and chronic toxicity testing. To implement this, they established an Interagency Coordinating Committee on the Validation of Alternative Methods in 1997. 

The National Institute of Environmental Health Sciences was directed by Public Law 103-43 to develop and validate alternative methods for acute and chronic toxicity testing. To implement this, they established an Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) in 1997. RBAs for the estrogen receptor vary considerably based on the source of the estrogen receptor proteins and isoforms (a or fS). Generally if the RBA for estradioTl7 S is set at 100, that of estrone is 15-60 and that of estriol is 0.2-30. 

ICCVAM Interagency Coordinating Committee on the Validation of Alternative Methods... 

For example, a guideline approved in 2009 by the CAC defines a validated method as an accepted test method for which validation smdies have been completed to determine the accuracy and reliability of this method for a specific purpose, referencing a definition provided by the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM). This definition is similar in content to definitions used by Eurachem, AOAC International, the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH), " and the VICH.19... 

ICCVAM. U.S. Department of Health and Human Services, National Toxicology Program, Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM). http //iccvam.niehs.nih.gov/... 

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