Interactions of medicines

The emergence of pharmacogenomics will also enhance the interaction of medicinal chemistry as a discipline with other disciplines, including the social sciences, ethics, and economics. Society has a difficult enough time paying for currently available dmg therapies. Who will pay for individualized therapies Will this further widen the chasm between have and have-not populations, between developed and developing nations ... 

Some elements found in body tissues have no apparent physiological role, but have not been shown to be toxic. Examples are mbidium, strontium, titanium, niobium, germanium, and lanthanum. Other elements are toxic when found in greater than trace amounts, and sometimes in trace amounts. These latter elements include arsenic, mercury, lead, cadmium, silver, zirconium, beryUium, and thallium. Numerous other elements are used in medicine in nonnutrient roles. These include lithium, bismuth, antimony, bromine, platinum, and gold (Eig. 1). The interactions of mineral nutrients with... 

The role of hydrogen bonding and hydrophobic interactions in medicinal effect of heterocycles 99AG(E)736. 

Figure 2.10 Illustration ofthe interaction of the EDQM with the overall regulatory system for medicines in Europe. Reproduced with permission of EDQM, EDQM, Council of Europe.

Preservative availability may be appreciably reduced by interaction with packaging materials. Examples include the permeation of phenolic preservatives into the rubber wads and teats of multi-dose injection or eye-drop containers and by their interaction with flexible nylon tubes for creams. Quaternary ammonium preservative levels in formulations have been significantly reduced by adsorption onto the surfaces of plastic and glass containers. Volatile preservatives such as chloroform are so readily lost by the routine opening and closing of containers that their usefulness is somewhat restricted to preservation of medicines in sealed, impervious containers during storage, with quite short use lives once opened. 

Bourne, L., CoUis, C. and Rice-Evans, C. (1994). The interaction of ruptured myocytes with low density lipoproteins. In Frontiers of Reactive Oxygen Species in Biolc and Medicine . (eds. K. Asada and T. Yoshikawa) pp. 469-470, Elsevier Science Pub. 

Oborne, D. J., Rogers, Y., Interactions of alcohol and caffeine on human reaction time. Aviation, -Space,-and -Environmental- Medicine 54(6), 528-534, 1983. 

Zsila F, Simonyi M, and Lockwood SF. 2003. Interaction of the disodium disuccinate derivative of meso-astaxanthin with human serum albumin From chiral complexation to self-assembly. Bioorganic Medicinal Chemistry letters 13(22) 4093 4100. 

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