Interaction disruption

Myelin galactolipids are essential for the proper formation of axo-glial interactions. Disruption of these interactions results in profound abnormalities in the... 

Methylisocyanate is a volatile, reaaive chemical which is highly irritant. Its reactivity means that when humans come into contact with it, it combines with components of body tissues such as the protein in eyes, skin, and lungs. It especially reacts with the sulphur atoms in proteins. These interactions disrupt the lining of the lungs and allow water to enter from surrounding tissues and blood. The result, known as pulmonary oedema, means the victim can drown because their lungs fill up with liquid. Studies in mice exposed to low levels have shown that the chemical is a very potent irritant to the lungs. 

Note The term hydrophobic is somewhat of a misnomer. In actuality, an attraction between solute and solvent molecules always exists. In the case of water, the solute-solvent interaction disrupts the local structure of water, which is dominated by hydrogen bonding. The stronger the solute-H20 interaction, the greater the likelihood that the local solvent structure will be disrupted by hydrated solute molecules, increasing the solubility of the solute. 

Varies the emission wavelength of isolated fluorescent proteins is different relative to bound proteins (e.g., SM-mediated interaction disruption can be seen directly)... 

T7 protein. By constrast, the evasin family of CKBPs and the poxvirus-encoded SECRET domain show narrow binding specificity. CKBPs may interfere with chemokine-GAC interactions, disrupting the presenttttion of chemokines on the surface of endothelial cells and the formation of chemokine gradients, or may sequester chemokines and block the interaction of chemokines to specific receptors and the induction of cell migration. 

In cardioviruses these are associated into pentamers by hydrophobic interactions (disrupted by urea), and the 12 pentamers which comprise the capsid are linked by electrostatic interactions (disrupted by chloride ions at pH 6). This model poses several intriguing questions. For example, are the three polypeptides in the protomer inteinvoven into a single trimeric imit or does each occupy a discrete spatial domain Are specific polypeptide species involved in the hydrophobic and electrostatic interactions between protomers and pentamers l /hat is the location and distribution of the 6 (VP4) polypeptides in the capsid Are there specific polypeptide species which interact directly with the virion MA ... 

Furthermore, these salts crystallize with noncentrosymmetric packing. An explanation for this required crystallization conld be that Conlomb interactions disrupt the dipole-dipole interactions. 

The pA a of the tertiary amino group in sensor 77 is 7.7 in 8 2 water/methanol. Above this pA a, where the amine is predominantly present as its free base, the amine lone pair ean participate in ET and a highly efficient quenching of the fluorescence emission is observed. When the pH is lowered below the pATa of the amine, so as to protonate it, the lone pair becomes involved in a bonding interaction, disrupting ET and resulting in a complete fluorescence revival. 

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