Integrins MAdCAM

The integrin a 4(3 7 is restricted to leukocytes and can bind not only to VCAM1 and fibronectin, but also to MAdCAM the mucosal addressin or homing receptor, which contains immunoglobulin-like domains related to VCAM-1. 

Berlin C, Berg EL, Briskin MJ Alpha 4 beta 7 integrin mediates lymphocytes binding to the mucosal vascular addressin MAdCAM-1. Cell 1993 74 185-195. 

Erie, D., Briskin, M., Butcher, E., Garcia-Pardo, A., Lazorovits, A. andTidswell, M. (1994). Expression and function of the MadCAM-1 receptor, integrin a4/37, on human leukocytes. J. Immunol. 153, 517-528. 

Figure 1 Movement of T lymphocytes from the blood into the lymph nodes, (a) Soluble or endothelial-displayed CCL21 ( ) binds CCR7 ( ). (b) The interaction induces a change in the conformation of the integrin tt4P7 from low affinity (I) to high affinity ( ). (c) The high affinity integrin then binds to mucosal addressin cell adhesion molecule-1, MAdCAM-1 (C), causing cell adhesion, (d) Directed cell migration between endothelial cells results.

Pachynski RK, Wu SW, Gunn MD, Erie DJ. Secondary lymphoid-tissue cytokine stimulates integrin alpha 4 beta 7-mediated adhesion of lymphocytes to mucosal addressin cell adhesion molecule-1 (MAdCAM-1) under flow. J Immunol 1998 161 953-956. 

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