Integrated Risk Information System Database

IRIS. 1990. Integrated Risk Information System (database). Washington, DC U.S. Environmental Protection Agency. 

Integrated Risk Information System (IRIS) Database... 

The Integrated Risk Information System (IRIS) is an electronic database containing information on human health effects that may result from exposure to various chemicals in the environment (IRIS 2007). The chemical hies in IRIS contain descriptive and quantitative information in the following categories ... 

Integrated risk information system (IRIS), database of the U.S. ERA. http //www.epa.gov/iriswebp/iris/index/html. 

The EPA controls the regulation of poisonous substances in the drinking water and in food, and provides an Integrated Risk Information System (IRIS) database for assessment in their Exposure Factors Handbook. They published drinking water standards in 1994 in terms of MCE in mg/L and as a health advisory RfD in mg/(kg day) of intake (Chapter 6). Some typical values are given in table 10.3, which shows a tremendous range of five orders of magnitude between the mildly toxic xylene and the extremely toxic white phosphoms. 

IRIS (Integrated Risk Information System) http //toxnet.nlm. nih. gov/cgi-bin/sis/ htmlgen7IRIS.htm Online database of the Environmental Protection Agency (EPA http //www.epa.gov) containing carcinogenic and non-carcinogenic health risk information on over 500 chemicals. Data have been scientifically reviewed and represent EPA consensus. 

The U.S. EPA approach to risk assessments for toxic chemicals follows the format described by the NRC. Because Hazard Identification and Dose-Response Assessment for an agent do not depend upon specific local situations, EPA assumes that risk assessors evaluating specific sites will not conduct independent analyses in these areas but will instead rely on the results of peer-reviewed evaluations by qualified authorities in toxicology. EPA is assembling an agency-wide database of such authoritative assessments, the Integrated Risk Information System (IRIS). 

Common Data Source Approach. Another approach is to use a common source of data for benchmarking a set of chemicals. Examples of potential data sources include Material Safety Data Sheets (MSDSs) from product manufacturers, the Hazardous Substances Data Bank (HSDB), the Integrated Risk Information System (IRIS), the International Uniform Chemical Information Database (lUClID), the High Rroduction Volume Information System (HRVIS), the Organisation for Economic Cooperation and Development (OECD) Screening Information Dataset (SIDS), and the Canadian Domestic Substances list... 

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