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Insulin transgenic mice

Poplonski L, Vukusic B, Brawling J, et al. Tolerance is overcome in beef insulin-transgenic mice by activation of low-affinity autoreaclive T cells. Eur J Immunol... [Pg.275]

Ottesen JL, Nilsson P, Jami J, Welguny D, Duhrkop M, Bucchini D, Havelund S, Fogh JM.The potential immunogenicity of human insulin and insulin analogues evaluated in a transgenic mouse model. Diabetalogia 1994 37 1178-1185. [Pg.358]

DDAH itself may also have potential as a therapeutic protein in disease states marked by excess N dimethyl-L-arginine. For example, overexpression of DDAH has beneficial effects in transgenic mouse models of graft coronary artery disease and can enhance sensitivity to insulin. DDAH may also have beneficial effects in treating chronic kidney disease, as overexpressed DDAH appears to slow progression of renal dysfunction in rat models. " Elevated asymmetric dimethylarginine (ADMA) levels have also been identified in the development of chronic lung diseases, specifically pulmonary fibrosis. However, the causal relationship between ADMA and these conditions has yet to be explored in detail. ... [Pg.138]

Zhao H, Yakar S, Gavrilova O, Sun H, Zhang Y, Kim H, Setser J, Jou W, LeRoith D (2004) Phloridzin improves hyperglycemia but not hepatic insulin resistance in a transgenic mouse model of type 2 diabetes. Diabetes 53 2901... [Pg.1899]

Kaplan PJ, Mohan S, Cohen P, Foster BA, Greenberg NM. The insulin-like growth factor axis and prostate cancer lessons from the transgenic adenocarcinoma of mouse prostate (TRAMP) model. Cancer Res 1999 59 2203-2209. [Pg.273]


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See also in sourсe #XX -- [ Pg.76 ]




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Transgenic mice

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