Insulin signalling activated protein

Insulin action in the adipocyte results in inhibition of lipolysis. Insulin signals activate AKT/PKB, which phosphorylates and activates PDE-3B [12], This results in cleavage of cAMP by PDE-3B, thus decreasing stimulated lipolysis (Fig. 3). Insulin signaling also activates protein serine phosphatases 1,2A, and 2C which contribute to the dephosphoiylation... 

Yenush L, Fernandez R, Myers MG Jr et al 1996 The Drosophila insulin receptor activates multiple signaling pathways but requires insulin receptor substrate proteins for DNA... 

In contrast to the receptors for insulin and growth factors (see p. 388), the cytokine receptors (with a few exceptions) have no tyrosine kinase activity. After binding of cytokine (1), they associate with one another to form homodimers, join together with other signal transduction proteins (STPs) to form dimers, or promote dimerization of other... 

Roselli. Saw palmetto extract sup- SR058 presses insulin-like growth fact or-1 signaling and induces stress-activated protein kinase/c-]un N-terminal kinase phosphorylation in human prostate epithelial cells. Endocrinology... 

Fig. 7.21. Activation of glycogen-bound protein phosphatase I by insulin. Insulin has a stimulating effect on glycogen synthesis by initiating the dephosphorylation and activation of glycogen synthase and the dephosphorylation and inhibition of glycogen phosphorylase. Both enzymes (substrate S in the figure) are dephosphorylated by protein phosphatase PPIG. Insulin mediates the activation of a protein kinase (insulin-sensitive protein kinase) within an insulin-stimulated signal pathway, which phosphorylates and thus activates protein phosphatase PPIG at the PI site.

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