Instrumentation database mining

Developments in mass spectrometry technology, together with the availability of extensive DNA and protein sequence databases and software tools for data mining, has made possible rapid and sensitive mass spectrometry-based procedures for protein identification. Two basic types of mass spectrometers are commonly used for this purpose Matrix-assisted laser desorption/ionization (MALDI)-time-of-flight (TOF) mass spectrometry (MS) and electrospray ionization (ESI)-MS. MALDI-TOF instruments are now quite common in biochemistry laboratories and are very simple to use, requiring no special training. ESI instruments, usually coupled to capillary/nanoLC systems, are more complex and require expert operators. We will therefore focus on the use of MALDI-... 

National Institute for Occupational Safety and Health (NIOSH) at http //www.cdc.gov/niosh/ (accessed July 11, 2010) and the Centers for Disease Control and Prevention (CDC) at http //www.cdc.gov/ (accessed July 11, 2010). Within both are hyperlinks to a number of free databases and search engines leading to full bibliographic citations for thousands of publications about mine safety, mine construction and stability, hazardous materials handling, equipment and instrumentation, mining byproducts, and training programs for safety and health. 

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