Insight regulatory

Murphy, J. A., 1996, Risk-Based Regulation Practical Experience in Using Risk-Related Insights to Solve Regulatory Issues, PSA 96, pp 945-948. 

This book, for the most part, is a stand-alone text. It addresses not only the fundamentals of PSA as a science, but insights on the regulatory framework affecting its development and apidication. In particular, it provides the basic methods of analysis that can be employed, available databases, an excellent set of examples, software resources, chapter summaries that tacilitate comprehension, and problem sets that are very well connected to the theory. While much has been written about probabilistic safety assessment over the last three decades, this is the most comprehensive attempt so far to provide a much needed college level textbook for the education of risk and safety professionals. It also provides a valuable reference for any individual curious enough about the risk and safety sciences to want to become much more informed. 

Caron, K. M., Soo, S. C., Wetsel, W. C., Stocco, D. M., Clark, B. J., and Parker, K. L. 1997. Targeted disruption of the mouse gene encoding steroidogenic acute regulatory protein provides insights into congenital lipoid adrenal hyperplasia. Proc. Natl. Acad. Sci. U.S.A., 94(21) 11540-11545. 

The molecular mechanism underlying the inhibition remains unclear. It could comprise the simple product inhibition due to binding of PS to either catalytic site or the regulatory site of PSS I. It is also possible that a putative regulator molecule may bind PSS I to repress the PSS I activity in the presence of excess PS and that Arg-95 of PSS I may be essential for this binding. Determination of the three-dimensional structure of PSS I may provide a new insight into the role of Arg-95 of PSS I in the feedback regulation mechanism. 

Clement, J.M., and Kent, C., 1999, CTP phosphochohne cytidylyltransferase insights into regulatory mechanisms and novel functions. Biochem. Biophys. Res. Commun. 257 643-650... 

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