Inositol synthesis

Inosine, 6-benzyloxy-9- -D-ribofuranosyl-2-dimethylamino-hydrogenolysis, 5, 558 Inosine, 2 -deoxy-alkylation, 5, 538 Inosine, 6-phenacylthio-dethiation, S, 559 Inosine 5 -monophosphate biosynthesis, 1, 88 Inosines, thio-synthesis, 5, 584 Inositol, D-l,4-anhydro-synthesis, 1, 416 Inositols synthesis, 1, 416 Insecticides... 

Glycosylatioti of Inositol Synthesis of the Terminal Carbohydrate Fragment in GPI-Anchors [47]... 

Other quercitols have been synthesized by catalytic hydrogenolysis of the corresponding inososes (see p. 180). All the known quercitols are shown, with their names, in formulas CXXXIX-CXLIV according to Angyal and Macdonald s proposals,6 the quercitol of acorn is called (+)-profo-quercitol, and natural viburnitol is named (—)-w 6o-quercitol the corresponding Fletcher-Anderson-Lardy names are (+)-1 -deoxy-mwco-inositol and ( —)-1-deoxy-WM/o-inositol. Synthesis of the four as-yet-unknown diastereomers should not present serious difficulties. 

Molina, Y., Ramos, S.E., Douglass, T., and Klig, L.S., 1999, Inositol synthesis and catabolism in Cryptococcus neoformans. Yeast 15 1657-1667. 

Sasaki, K., and Taylor, I.E.P., 1986, myo-Inositol synthesis from [l-3H]glucose in Phaseolus vulgaris L. during early stages of germination. Plant Physiol. 81 493—496. 

Figure 1. Inositol synthesis and catabolism. Inositol is synthesized from glucose-6-phosphate (Glucose 6-P) by the action of L-wyo-inositol 1-phosphate synthase (MIPS) and wyo-inositol monophosphatase (IMP). IMPase is also required for the last step of inositol (1,4,5)P3 second messenger breakdown. The first step in inositol catabolism utilizes the wyo-inositol oxygenase (MIOX) enzyme, which cleaves the inositol ring to form D-glucuronic acid.

There continues to be sustained interest in controlling MIPS expression to increase or decrease inositol synthesis in plants. Since inositol may function as an osmolyte in plants, increasing inositol levels in transgenic plants could lead to better stress protection in crop species (Bohnert et al., 1995). Further, decreases in inositol synthesis may allow for decreased production of environmental... 

We have detailed the MIPS, IMP, and MIOX genes and proteins with an overall focus on determining gene function within the inositol synthesis and catabolism pathway. Each of these enzymes contributes to the overall cellular need for inositol and its breakdown products. One central theme to emerge from our... 

McGraw, P., and Henry, S.A., 1989, Mutations in the Saccharomyces cerevisiae opi3 gene Effects on phospholipid methylation, growth and cross-pathway regulation of inositol synthesis. Genetics 122 317-330. 

Par, Y., Hong, Y., Kim, S., Piccariello, T, Farese, R.V., and Larner, J. In vivo chiro-inositol metabohsm in the rat a defect in chiro-inositol synthesis from myoinositol and an increased incorporation of chiro-[ H]inositol into phospholipid in the Goto-Kakizaki (GK) rat. Mol. Cells, 1998, 8, 301-309. 

HI 26 Trehalase and inositol synthesis Glucopyranosyl antibiotics Validamycin Specific for rice sheath blight Rhizoctonia solani)... 

Tonephin, see also under Pressor hormone, of posterior pituitary renal activity, VII, 410 TonUa utilia, inositol synthesis by, VI, 197... 

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