Inositol-1,4,5-trisphosphate -induced

Taniguchi M., Wang D. and Halpem M. (2000). Chemosensitive conductance and inositol 1,4,5-trisphosphate-induced conductance in snake vomeronasal receptor neurons. Chem Senses 25, 67-76. 

McGrath J, Solter D 1984 Inability of mouse blastomere nuclei transferred to enucleated zygotes to support development invitro. Science 226 1317-1319 Miyazaki S 1988 Inositol 1,4,5-trisphosphate-induced calcium release and guanine nucleotidebinding protein-mediated periodic calcium rises in golden hamster eggs. J Cell Biol 106 345-353... 

Gilabert JA, Parekh AB 2000 Respiring mitochondria determine the pattern of activation and inactivation of the store-operated Ca2+ current Icrac- EMBO J 19 6401-6407 lino M 1990 Biphasic Ca2+ dependence of inositol 1,4,5-trisphosphate-induced Ca2+ release in smooth muscle cells of the guinea pig taenia caeci. J Gen Physiol 95 1103-1122 Iizuka K, Yoshii A, Dobashi K, Horie T, More M, Nakazawa T 1998 InsP3, but not novel Ca2+ releasers, contributes to agonist-initiated contraction in rabbit airway smooth muscle. J Physiol 511 915-933... 

Finch EA, Turner TJ, Goldin SM 1991 Calcium as a coagonist of inositol 1,4,5-trisphosphate-induced calcium release. Science 252 443-446... 

Miyakawa T, Maeda A, Yamazawa T, Hirose K, Kurosaki T, lino M. Encoding of Ca +signals by differential expression of IP3 receptor subtypes. 1. EMBO J. 1999 18 1303-1308. lino M. Biphasic Ca + dependence of inositol 1,4,5-trisphosphate-induced Ca + release in smooth muscle cells of the guinea pig taenia caeci. J. Gen. Physiol. 1990 95 1103-1122. 

Fohr KJ, Scott J, Ahnert-Hilger G et ol. (1989) Characterization of the inositol 1,4,5,-trisphosphate-induced calcium release from permeabilized endocrine cells and its inhibition by decavanadate and p-hydroxymercuribenzoate. Biochem. J. 262 83-89. 

Hirose, K., lino, M.. and Endo, M. (1993) Caffeine inhibits Ca(2+)-mediated potentiation of inositol 1,4,5-trisphosphate-induced Ca release in permeabilized vascular smooth muscle cells. Biochemical Biophysical Research Communications, 194 726-732. 

Combettes, L. P. Champeil. 1994. Calcium and inositol 1,4,5-trisphosphate-induced Ca release. Science 265 813. 

Swillens, S., L. Combettes P. Champeil. 1994. Transient inositol 1,4,5-trisphosphate-induced Ca release A model based on regulatory Ca -binding sites along the permeation pathway. Proc. Natl. Acad. ScL USA 91 10074-8. 

Somlyo AV, Somlyo AP 1971 Strontium accumulation by sarcoplasmic reticulum and mitochondria in vascular smooth muscle. Science 174 955-958 Somlyo AV, Bond M, Somlyo AP, Scarpa A 1985 Inositol-trisphosphate induced calcium release and contraction in vascular smooth muscle. Proc Natl Acad Sci 82 5231-5235 Somlyo AV, Horiuti K, Trentham DR, Kitazawa T, Somlyo AP 1992 Kinetics of Ca2+ release and contraction induced by photolysis of caged D-myo-inositol 1,4,5-trisphosphate in smooth muscle the effects of heparin, procaine, and adenine nucleotides. J Biol Chem 267 22316-22322... 

MalhpR., 1998, Role of 1,4,5-inositol trisphosphate-induced Ca 2+ release in pollen tube orientation. Sex. Plant Reprod. 11 231-235. 

Smith, P.M., Harmer, A.R., Letcher, A.J., and Irvine, R.F., 2000, The effect of inositol 1,3,4,5-tetrakisphosphate on inositol trisphosphate-induced Ca2+ mobilization in freshly isolated and cultured mouse lacrimal acinar cells. Biochem. J. 347(Pt 1) 77-82. 

Somlyo, A.V., Bond, M., Somlyo, A.P., and Scarpa, A. (1985) Inositol trisphosphate-induced calcium release and contraction in vascular smooth muscle. Proc.Natl.Acad.Sci.USA, 82 5231-5235. 

Somlyo AV (1980) Ultrastructure of vascular smooth muscle. The Handbook of Physiology The Cardiovascular System, Vol. II Vascular Smooth Muscle. DF Bohr, AP Somlyo, HV Sparks, eds., American Physiological Society, Bethesda, Md., pp. 33-67. Somlyo AV, Bond, M, Somlyo, AP Scarpa, A (1985) Inositol trisphosphate- induced calcium release and contraction in vascular smooth muscle. Proc Natl Acad Sci USA 82 5231-5235... 

Zholos, A.V., S. Komori, H. Ohashi T.B. Bolton. 1994. C f inhibition of inositol trisphosphate-induced Ca release in single smooth muscle cells of guinea-pig small intestine. J. Physiol. 481.1 97-109. 

I Kojima, H Shibata, E Ogata. (1986). Pertussis toxin blocks angiotensin II-induced calcium influx but not inositol trisphosphate production in adrenal glomerulosa cell. FEBS Lett 204 347-351. 

Further support for the hypothesis that Ca2+ plays a central role in regulating phytoalexin accumulation is provided by experiments in which the turnover of phosphatidylinositol was measured in the plasma membrane of elicitor-treated carrot cells [17]. The carrot cells were first labelled with [3H]myo-inositol and, after the addition of elicitors, acid extracts of the cells were analyzed chromatographically for the production of inositol trisphosphate (IP3). In cells treated with elicitor, the release of radioactive IP3 increased with time and attained a maximum at 3 - 5 min after treatment. Phospholipase activity responsible for the degradation of phosphorylated phosphatidylinositol increased correspondingly. Several reports have shown that IP3 induces rapid release of Ca2+ from intracellular stores in animal cells [18, 19]. Studies on plant cells have also demonstrated that exogenous IP3 releases Ca2+ from microsomal preparations at micromolar concentrations, although only limited... 

After activation of the TCR, there is induction of Src family tyrosine kinase (p56lek), which phosphorylates phospholipase Oyl. This is followed by the hydrolysis of phosphatidylinositol 4,5-bisphosphate, resulting in the production of diacyl-glycerol (DAG) and inositol trisphosphate (IP3). Protein kinase C is activated by DAG, which phosphorylates Ras. Ras is a GTPase and its phosphorylation induces Raf and initiation of MAP kinase signaling pathway. IP3 is involved in calcium-dependent activation of IL-2 gene expression via nuclear factor of activated T cells (NFAT). 

Boekhoff I., Raming K. and Breer H. (1990b) Pheromone-induced stimulation of inositol-trisphosphate formation in insect antennae is mediated by G-proteins. J. Comp. Physiol. B 160, 99-103. 

Blackmore and Exton [5] have provided much evidence that the potentiation by glucagon of the intracellular Ca2+ mobilization induced by vasopressin is due to an enhancement of inositol trisphosphate accumulation (Fig. 11). This is probably true for its synergistic interaction with other Ca2+-mobilizing agonists. All the actions of... 

Figure 2.14. Histamine-induced accumulation of [3HJinositol 1-phosphate (IP,) [3HJinositol bisphos-phate (IP2) and [3H]inositol trisphosphate (IP3) in slices of guinea-pig cerebellum. Concentration-response curves were obtained in the presence (O) and absence (9) of3 x 10 8 M mepyramine. Data...

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