Inositol 1,4,5-trisphosphate correlation

DeWald, D.B., Torabinejad, J., Jones, C.A., Shope, J.C., Cangelosi, A.R., Thompson, J.E., Prestwich, G.D., and Hama, H., 2001, Rapid accumulation of phosphatidylinositol 4,5-bisphosphate and inositol 1,4,5-trisphosphate correlates with calcium mobilization in salt-stressed Arabidopsis. Plant Physiol. 126 759-769. 

Further studies have revealed that pumiliotoxin B interacts with voltage-dependent sodium channels to elicit an increased influx of sodium ions (101,102) and, in brain and heart preparations, a stimulation of phosphoino-sitide breakdown (101,103-106). The phosphoinositide breakdown can, via inositol trisphosphate, cause release of calcium from internal storage sites. The cardiotonic activity of pumiliotoxin B and various congeners and synthetic analogs correlates well with the stimulation of phosphoinositide breakdown (104,105). A number of studies on stimulation of sodium uptake by pumiliotoxin B and inhibition by local anesthetics and other agents have appeared (106-108). The effects of pumiliotoxin B on neuromuscular preparations have been reinterpreted as due primarily to effects on sodium channels, although additional direct effects on calcium mobilization remain possible (109). It has recently been proposed that pumiliotoxin B enhances the rate of activation of sodium channels (110). One characteristic effect of pumiliotoxin B is to elicit repetitive firing in neurons, apparently because of effects on sodium channel function (109-111). 

Basset, O., Boittin, F.X., Dorchies, O.M., Chatton, J.Y., van Breemen, C., and Ruegg, U.T., 2004, Involvement of inositol 1,4,5-trisphosphate in nicotinic calcium responses in dystrophic myotubes assessed by near-plasma membrane calcium measurement, J Biol Chem, 279, pp 47092 17100. Baumbach, L.L., Chamberlain, J.S., Ward, P.A., Farwell, N.J., and Caskey, C.T., 1989, Molecular and clinical correlations of deletions leading to Duchenne and Becker muscular dystrophies, Neurology, 39, pp 465 174. 

Haug, L.S., Ostvold, A.C., Cowburn, R.F., Garlind, A., Winblad, B., Bogdanovich, N., and Walaas, S.I., 1996, Decreased inositol (l,4,5)-trisphosphate receptor levels in Alzheimer s disease cerebral cortex Selectivity of changes and possible correlation to pathological severity. 

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