Inositol phosphoglycan

Application to glycosylphosphatidylinositol (CPI) anchor and inositol phosphoglycan (IPG) synthesis... 

Synthesis of inositol phosphoglycans (IPGs) (71), analogues to second messengers of insulin, has been described. These derivatives contain the glucosamine (a 1-6) myo-inositol 1,2 cyclic phosphate motif and the thiol-terminated spacers for efficient coupling to maleimide functionalized solid phases or proteins. ... 

Kunjara, K., Caro, H.N., McLean, P., and Rademacher, T.W. Tissue specific release of inositol phosphoglycans. Biopo-... 

R., Mato, J.M., and Varela-Nieto, I. Glycosyl-phosphatidylinositol/inositol phosphoglycan a signaling system for the low-affinity nerve growth factor receptor. Proc. Natl. Acad. Sci. USA, 1991, 88, 8016-8019. 

Paneda, C., Villar, A.V., Alonso, A., Goni, F.M., Varela, F., Brodbeck, U., Leon, Y., Varela-Nieto, I. and Jones, D.R. Purification and characterization of insulin-mimetic inositol phosphoglycan-like molecules from grass pea (Lathyrus sati-vus) seeds. Mol. Med., 2001, 7, 454—460. 

Caro, H.N., Kunjara, S., Rademacher, T.W, Leon, Y, Jones, D.R., Avila, M.A., and Varela-Nieto, I. Isolation and partial characterisation of insulin-mimetic inositol phosphoglycans from human liver. Biochem. Mol. Med., 1997, 61, 214-228. 

C.W., and Rademacher, T.W. Inositol phosphoglycans and signal transduction systems in pregnancy in preeclampsia and diabetes evidence for a significant regulatory role in preeclampsia at placental and systemic levels. Mol. Genet. Metab., 2000, 69, 144-158. 

T.W. Inositol phosphoglycans and the regulation of the secretion of leptin in vitro effects on leptin release from adipocytes and the relationship to obesity. Mol. 

VarelaNieto, I., Leon, Y., and Caro, H.N. (1996). Cell signalling by inositol phosphoglycans from different species. Comp. Biochem. Physiol. B. 115,223-241. 

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