Biosynthesis inositol

Loewus, F.A., 1990a, Inositol biosynthesis, metabolism Precursor role and breakdown. In Morre, D.J., Boss, W.F., and Loewus, FA. (eds.), Inositol Metabolism in Plants. Wiley-Liss, New York, NY, pp. 13-19. 

Hasegawa, R., and Eisenberg, E, Jr., 1981, Selective hormonal control of myo-inositol biosynthesis in reproductive organs and liver of the male rat. Proc. Natl. Acad. Sci. U.S.A. 78 4863-4866. 

Vaden, D.L., Ding, D., Peterson, B., and Greenberg, M.L., 2001, Lithium and valproate decrease inositol mass and increase expression of the yeast inol and ino2 genes for inositol biosynthesis. J. Biol. Chem. 276 15466-15471. 

This review aims to present some of the more interesting molecules containing inositol synthesized by bacterial and archaeal cells, and to describe what is known about their biosynthesis. A brief review of bacterial and archaeal inositol biosynthesis and catabolic activities is also provided. 

MIPS is the rate-limiting step in mvo-inositol biosynthesis. Regulation of the enzyme from yeast has been examined in detail since there are multiple ways to... 

Nigou, J., Dover, L.G., and Besra, G.S., 2002, Purification and biochemical characterization of Mycobacterium tuberculosis SuhB, an inositol monophosphatase involved in inositol biosynthesis. Biochemistry 41 4392 1398. 

Culbertson, M.R., Donahue, T.F., and Henry, S.A., 1976a, Control of inositol biosynthesis in Saccharomyces cerevisiae Properties of a repressible enzyme system in extracts of wild type (.Ino+) cells. J. Bacteriol. 126 232-242. 

Greenberg, M.L., Reiner, B., and Henry, S.A., 1982b, Regulatory mutations of inositol biosynthesis in yeast Isolation of inositol-excreting mutants. Genetics 100 19-33. 

Keywords Inositol biosynthesis, lL-myo-inositol 1-phosphate synthase, D-glucose 6-phosphate, enzyme structure, enzyme mechanism. 

The first step in the pathway is the synthesis of PI from CDP-diacylglycerol and myo-inositol by PgsA (Rv2612c) [275]. Myo-inositol is uncommon in prokaryotes, but inositol phosphates and inositol-containing phosphoglycans are important in eukaryotic signaling pathways. The mycobacterial enzymes responsible for myo-inositol biosynthesis have been characterized [276,277]. 

The mechanism of cyclopentane ring formation of allosamizoline may take place via pathway A or B during inositol biosynthesis, whereas via pathway C during shikimic acid biosynthesis (Scheme 1). This was based on a study using [3- H]-, [4- H]-, [5- H]-and [6- H2]-D-glucosamine feeding in experiments which indicated that the cyclization to form the cyclopentanoid moiety of allosamizoline is presumed to proceed via a 4-keto or... 

Loewus, F.A. Loewus, M.N. Myo-inositol biosynthesis and metabolism. Biochemistry of Plants 3. Carbohydrates structure and functions, Preiss, J., Ed. Academic press, London, 1980, pp. 43—100. 

Loewus F A, Loewus M W 1980 wyo-Inositol Biosynthesis and metabolism. In Preiss J (ed) The biochemistry of plants, vol 3. Academic Press New York, 43-76... 

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