Innovation continued structure, technological

There is little doubt that bacteria in general, and actinomycetes in particular, in combination with the novel technologies and approaches for natural products discovery reported in the last years will continue to provide high levels of structural diversity and leads required for the development of future innovative drugs. 

Increasing work in the field of HME and published literature reveals the innovative aspects of this technology. These include, but are not limited to, in situ salt formation, quick dispersing systems with foam like structures, coextrusion to prepare extrudates in the form of laminar structures with multiple layers, nanoparticles released from molecular dispersions manufactured by melt extrusion, and twin-screw melt granulation, which can provide continuous manufacturing of granules yielding consistent product quality attributes. 

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