Innate immunity, polymorphonuclear

At higher chemokine concentrations, polymorphonuclear leukocytes are activated to produce oxygen radicals and to degranulate (Taub et al., 1996). Several granule proteins, including the defensins, azurocidin, and cathepsin G, are themselves chemotactic for mononuclear cells and presumably serve as signals that help convert acute into chronic inflammatory responses and thus promote the conversion of innate into adaptive immune responses (Chertov et al., 1996, 1997). Thus, chemokines have the potential to activate a number of downstream... 

Inflammation is a complex and well-coordinated response of the innate and adaptive immune system following infection or injury. This process is characterized by a vascular response and recruitment of circulating leukocytes, defined initially by polymorphonuclear granulocytes followed by monocytes, which differentiate locally into macrophages [47]. 

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