Injectable capsaicin

Remadevi R, Szallasi A. (2008) Adlea (ALGRX-4975), an injectable capsaicin (TRPVl receptor agonist) formulation for longlasting pain relief. IDrugs 11 120-132. 

Rats injected intravenously accumulated capsaicin primarily in the brain and spinal cord 3 min after dosing, with lower levels found in the liver and blood, while 10 min after dosing, the greatest concentrations remained in the spinal cord [169]. Subcutaneously injected capsaicin was detected in all tissues of rat 10 min... 

Generic Name injectable capsaicin Trade Name Adlea ... 

Remadevi R, Szallisi A. Adlea(ALGRX-4975) an injectable capsaicin (TRPVl Receptor agonist) formulation for longstanding pain relief. IDrugs 2008 11(2) 120-132. 

Boc-Tyr-Gly-NHO-Bz, a representative of a novel class of cysteine protease inhibitors, when coadministered with dynorphin A or dynorphin B, significandy prolong antinociception induced by i.t. injection of these dynorphins in the mouse formalin and capsaicin tests (Tan-No et al., 1996, 2005a). This observation indicates that cysteine proteases may be important for terminating dynorphin A- and dynorphin B-induced antinociception. 

Wu, J., Lin, Q, McAdoo, D. J., and Willis, W. D. (1998). Nitric oxide contributes to central sensitization following intradermal injection of capsaicin. NeuroReport 9, 589—592. 

INTRAPLANTAR INJECTION OF BERGAMOT ESSENTIAL OIL INTO THE MOUSE HINDPAW EFFECTS ON CAPSAICIN-INDUCED NOCICEPTIVE BEHAVIORS... 

Fig. 2. Antinociceptive effects of intraplantar BEO in the capsaicin test. BEO was injected into the plantar surface of the hindpaw 10 min prior to injection of capsaicin (50 ng/paw). Jojoba oil was used as a control, which was without affecting the capsaicin-induced nociceptive response. Data are means + S.E.M. in — 10 mice per group). p < 0.001, p < 0.01 when compared with Jojoba oil-treated controls by Dunnett s test.

Sakurada, T., Sakurada, S., Morrone, L. A., and Bagetta, G. (2008). Intraplantar injection of bergamot essential oil into the mouse hindpaw Effects on capsaicin-induced nociceptive behavior. In XI Workshop on Apoptosis in Biology and Medicine , Abstract book. 

Sorkin, L. S., and McAdoo, D. J. (1993). Amino acid and serotonin are released into the lumbar spinal cord of the anesthetized cat following intradermal capsaicin injections. Brain Res. 607, 89-98. Strauss, U., Wissel, K., Jung, S., Wulff, H., Hansel, W., Zhu, J, Rolfs, A, and Mix, E. (2000). K+ channel-blocking alkoxypsoralens inhibit the immune response of encephalitogenic T line cells and lymphocytes from Lewis rats challenged for experimental autoimmune encephalomyelitis. Immunopharmacology 48, 51-63. 

Tsuda M, Inoue K, Salter MW (2005) Neuropathic pain and spinal microglia a big problem from molecules in small glia. Trends Neurosci 28 101-107 Tu Y, Sun RQ, Willis WD (2004) Effects of intrathecal injections of melatonin tmtilogs on capsaicin-induced secondary mechanical tillodynia and hyperalgesia in rats. Pain 109 340-350 Tbboly G, Benedek G, Horvath G (2009) Selective disturbance of pain sensitivity after social isolation. Physiol Behav 96 18-22... 

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