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Inhibition of enzyme reactions

The function of enzyme-based biosensors may be severely restricted by inhibitors. The inhibition is either reversible or results in an irreversible inactivation of the enzyme. [Pg.46]

Inhibitors structurally related to the substrate may be bound to the enzyme active center and compete with the substrate (competitive inhibition). If the inhibitor is not only bound to the enzyme but also to the enzyme-substrate complex, the active center is usually deformed and its function is thus impaired in this case the substrate and the inhibitor do not compete with each other (noncompetitive inhibition). Competitive and noncompetitive inhibition effect the enzyme kinetics differently. A competitive inhibitor does not change but increases. Km (Fig. 25a) in contrast, noncompetitive inhibition results in an unchanged Km and an increased vmax (Fig. 25b). Some enzymes, e.g. invertase, are inhibited by high product concentration (product inhibition). [Pg.46]

A modulator (or effector) is a substance which can combine with enzymes to alter their catalytic activities. An inhibitor is a modulator which decreases enzyme activity. It can decrease the rate of reaction either competitively, noncompetitively, or partially competitively. [Pg.31]

It is common in biochemical engineering to use the term dilution rate rather than the term residence time, which chemical engineers are more familiar. In this book, both terminologies are used. [Pg.31]


J. H. Weisburger, C. M. Goodall, Steric Inhibition of Enzyme Reactions. Lack of Enzymatic Hydrolysis of 2, 4, 6 -Trimethyl-Acetanilide , Life Sci. 1968, 7, 263-267. [Pg.173]

The current theory on the mode of action of copper compounds is that the copper ion, Cu, is the active component, which is released from the different salts on the leaf surfaces. The copper ions in the presence of CO2 from the air and the organic acids excreted from the plant and/or fungal spores interact together to produce the resultant activity. The copper ions and complex-bound copper are capable of penetrating the spores and lead to the inhibition of enzyme reactions. This can occur by the removal of other important metals from their compounds by chelation and also by blocking or interacting with the sulfhydryl groups of the spore enzymes. [Pg.189]

Inhibition of Enzyme Reactions 391 Multiple Enzyme and Substrate Systems 392... [Pg.6]


See other pages where Inhibition of enzyme reactions is mentioned: [Pg.31]    [Pg.310]    [Pg.488]    [Pg.391]    [Pg.46]    [Pg.1501]    [Pg.1516]    [Pg.409]    [Pg.411]    [Pg.415]    [Pg.44]    [Pg.1522]    [Pg.25]    [Pg.366]    [Pg.367]    [Pg.369]    [Pg.371]    [Pg.171]    [Pg.172]    [Pg.222]   
See also in sourсe #XX -- [ Pg.46 ]

See also in sourсe #XX -- [ Pg.409 ]

See also in sourсe #XX -- [ Pg.436 , Pg.437 , Pg.438 , Pg.439 , Pg.440 ]

See also in sourсe #XX -- [ Pg.366 ]




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