Inhalation reservoir systems

The metering of dry powder inhalers is closely linked to the device itself and may be divided into three common systems capsules, multidosing blister packs, and reservoir systems. The consideration that goes into these metering systems include convenience to the patients, stability on storage, compatibility with product, and ease of filling. 

Virus is found worldwide. The natural reservoir is the common house mouse (Mus musculus) and the virus is shed in their urine. Infection occurs after inhalation of dust contaminated with excreta from infected mice or from aerosol of animal blood or fluids. Disease can be passed to rodent pets such as mice and hamsters. Does not produce disease in animals. The virus normally has little effect on healthy people but can be deadly for people whose immune system has been weakened. This is a biosafety level 3 agent. 

The reservoir incorporated within the Circulaire nebulizer system may help increase the inhaled proportion of aerosol from a given fill volume compared to the same driving nebulizer without incorporation of the valved reservoir bag system. Like the Halolite, this implies reconsideration of prescribed doses and volume fills of drug solution to avoid overdosing. The extent to which the droplet size from conventional nebulizers is affected by adaptations in Halolite and Circulaire nebulizer system is not clear. Meaning in vitro measurements (e.g., European standard) characterizing droplet size from either system is not available. 

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