Inhalant chemicals hydrocarbon mixtures

If the mixture of concern consists of a set of toxicologically well-characterized fractions, the mixture may be fractionated and its risk can be assessed based on the risks of the individual fractions for example, the hazard quotients for the individual fractions can be combined using a HI calculation that accounts for the combined action of the fractions. An example involves the fractionation of total petroleum hydrocarbons (TPHs) at contaminated sites for use in risk assessment. In this approach the TPH at a site is divided into analytically defined fractions, and then oral and inhalation toxicity values are assigned to these fractions for use in risk assessment (MADEP 2002,2003). A single surrogate chemical from each fraction is used to represent the risk for the entire fraction. The method does not totally account for all of the unidentified material, but does reflect differences in chemical composition across various sites and provides a reasonable method for calculating potential health risks. 

DOT CLASSIFICATION 6.1 Label Poison SAFETY PROFILE Poison by inhalation and intravenous routes. Moderately toxic by ingestion and subcutaneous routes. An irritant. Questionable carcinogen with experimental carcinogenic data. Flammable when exposed to heat or flame. Moderately explosive by spontaneous chemical reaction. To fight fire, use water, CO2, dry chemical. Dehalogenation by reaction with alkalies, metals, etc., will produce spontaneously explosive chloroacetylenes. Violent reaction with NaK aUoy + bromoform. Mixtures with potassium are very shock-sensitive explosives. When heated to decomposition it emits highly toxic fumes of Cl". See also CHLORINATED HYDROCARBONS, ALIPHATIC. 

Verhaar et al. (1997), however, recently reported on progress in developing PBPK/PD models for use in assessing human health risks from exposure to JP-5, a Navy Jet petroleum fuel containing a complex mixture of hydrocarbons in the C9-C18 range. Verhaar et al. (1997) noted that their in-progress development of a PBPK/PD model for JP-5 is focused on the prediction of kinetics of JP-5 components in relevant tissues after acute inhalation exposure and the resultant toxicity (neurological effects linked to the dissolution of xenobiotic chemicals in the membrane of nerve cells). Verhaar et al. (1997) discussed how the development of PBPK/PD model(s) for complex mixtures involves ... 

---