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Ingenol-hexadecanoate

A number of plant toxins are cyclic members of this series. Huratoxin is the piscicidal constituent of Hura crepitans (Euphorbiaceae). X-Ray analysis showed 34 jjg structure [117 R - H, R = CH CH-CH CH(CH2)8Me] was related to daphnetoxin (117 R = H, R = Ph). Mezerein (117) which is the toxic principle of Daphne mezereum, containsthe cinnamylidene acetic ester (R ) and orthobenzoate (R ) units. Ingenol (118), as its 3-hexadecanoic acid ester, is an irritant isolated from Euphorbia ingens Its structure was determined by X-ray analysis of the triacetate. [Pg.150]

Ingenol-3-hexadecanoate is one member of a structurally diverse group of compounds, including the phorbol esters, the teleocidins, and the aplysiatoxins, which are believed to promote tumor formation by activating protein kinase C. [Pg.170]

See other pages where Ingenol-hexadecanoate is mentioned: [Pg.543]    [Pg.103]    [Pg.40]    [Pg.324]    [Pg.103]    [Pg.288]    [Pg.543]    [Pg.103]    [Pg.40]    [Pg.324]    [Pg.324]    [Pg.103]    [Pg.288]   
See also in sourсe #XX -- [ Pg.103 ]

See also in sourсe #XX -- [ Pg.40 ]

See also in sourсe #XX -- [ Pg.103 ]

See also in sourсe #XX -- [ Pg.29 , Pg.103 ]



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Hexadecanoate

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