Infralimbic cortex

Mueller, D., Porter, J. T. Quirk, G. J. (2008). Noradrenergic signaling in infralimbic cortex increases cell excitability and strengthens memory for fear extinction. J. Neurosci., 28, 369-375. 

Architecture of the MOB (A, B) and primary olfactory cortex (POC, C). A and B Coronal section (Nissl stain) of the rat MOB at low (A) and high (B) magnifications. C Coronal section through the rat brain showing several structures of the POC. Abbreviations ac, anterior commissure Acb, nucleus accumbens AONvp, anterior olfactory nucleus, ventroposterior division DP, dorsal peduncular cortex IL, infralimbic cortex Pir, piriform cortex SEL, subependymal layer Scale bar in A and C = 1 mm. Modified from Handbook of Chem. Neuroanat. Integrated Sys. CNS, Vol. 12, Part III, Chapter III, The Olfactory System, M. Shipley etal., pp. 469-573,1996, with permission from Elsevier... 

Torrealba F, Muller C (1999) Ultrastructure of glutamate and GABA immunoreactive axon terminals of the rat nucleus tractus solitarius, with a note on infralimbic cortex afferents. Brain Res 820 20-30. 

Vertes RP. Differential projections of the infralimbic and pielimbic cortex in the rat. Synapse 2004 51 32-58. 

In the rat, the limbic or ventral striatum, which includes the ventral striatum proper and the ventromedial portion of the CPu, receives extensive input from limbic structures, such as the hippocampus and amygdala, as well as prefrontal cortical areas subserving limbic and autonomic functions (orbital, infralimbic, prelimbic and agranular insular fields) (see Section 7.2). In primates, the limbic striatum comprises the NAc and the most ventral parts of the caudate and the putamen and, as in the rat, receives input from the hippocampus and amygdala its cortical input is further defined by projections deriving from the orbitofrontal cortex and the anterior cingulate area. 

The NAc core and the shell show differences in their input-output organization. For example, although hippocampal projections reach both the core and the shell, the ventral subiculum projects to the shell, whereas the dorsal subiculum projects to the core. Different regions of the prefrontal cortex also target differentially the shell and core the prelimbic area projects to the core, whereas the infralimbic and piriform cortices project to the shell (Berendse et al., 1992). Amygdaloid fiber subsets are also differentially distributed to the two main NAc territories. 

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