Influenza vaccines drug administration

DoD has two distinct roles during the acquisition of drugs and biologies for CBW defense purchaser and developer. As purchaser of a drug approved by the U.S. Food and Drug Administration (FDA) for which a commercial market exists, DoD simply buys what it needs at the market price DoD acquisition of influenza vaccine is a good example of this. However, when the market is limited mainly to military use, even for a drug that is approved by FDA, DoD s role as pur-... 

The manufacturers advise that antivirals active against influenza such as oseltamivir and rimantadine should not be given until 2 weeks after the administration of live influenza virus vaccines, and that these vaccines should not be given until 48 hours after stopping the antiviraL This is because of the theoretical concern that these antiviral drugs will inhibit replication of live vaccine virus, and therefore reduce its effect. Note that most influenza vaccines are inactivated (split virion or surface antigen), and that these would not be expected to be affected by antivirals active against influenza. 

Drug-drug interactions Coadministration of tramadol with vitamin K antagonists increases INR [81 ]. Findings were confirmed by a case-control trial assessing patients on tramadol who were placed on a vitamin K antagonist [82 ]. Patients on rifampicin experienced decreased oral bioavailability of lOO-mg tramadol and decreased durabon of acHon of intravenous 50-mg tramadol [83 -]. A case series of two elderly women on 100-mg oral tramadol demonstrated acute onset of hallucinations after administration of influenza vaccine [84 ]. 

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