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Influenza host resistance assay

MODELS OF HOST RESISTANCE TO INFECTIONS Influenza Host Resistance Assay... [Pg.165]

The algorithm in Table 5.1-2 provides a path to ensure a thorough immuno-toxicological safety evaluation for therapeutics. The influenza host resistance assay is a well-characterized model and can serve as a biomarker for evaluating the overall health of the immune system. Therapeutic agents can be evalu-... [Pg.165]

B) Mechanistic immune function assays associated with influenza host resistance assay that may or may not be included ... [Pg.165]

The therapeutic agent should be further tested in the murine cytomegalovirus (MCMV) latent virus reactivation model if results from the influenza host resistance assay indicate a decreased functional activity for either NK, CTL, or TDAR, or a decrease in CD4+ cells as observed by immunopheno-typing. The MCMV latent virus reactivation model is discussed in detail below. The test article should be tested in the Streptococcus pneumoniae systemic model for encapsulated bacteria if immunophenotyping or histopathology, done in conjunction with the influenza host resistance model, reveals a decrease in the number of marginal zone B (MZB) cells. MZB cells are critical in host defense against bloodborne encapsulated bacteria and this host resistance assay is discussed in detail below. [Pg.167]

The influenza host resistance assay is able to evaluate the overall health of the immune system, as well as to evaluate mechanistic immunological function of... [Pg.172]

The influenza virus host resistance model has been characterized in mice and rats, and has been widely used to evaluate the potential immunotoxicity of therapeutics. Influenza virus is used as the infectious challenge agent and administered intranasally in a 28-day repeat-dose study. Mice or rats are dosed for 7 days, infected and then dosed for an additional 21 days. Viral clearance is quantified by measuring infectious virus (plaque-forming units) at various times following infection. Dexamethasone may be used as a positive immunomodulatory control. This host resistance assay has been used in Balb/c, C57BL/6, and B6C3F1 mice and Fischer 344 (CDF), Brown Norway, and... [Pg.166]

See other pages where Influenza host resistance assay is mentioned: [Pg.167]    [Pg.167]    [Pg.70]    [Pg.570]    [Pg.205]    [Pg.190]    [Pg.263]   
See also in sourсe #XX -- [ Pg.206 ]



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