Inflammation therapeutic approach

Rahman I. and MacNee W. (2000). Regulation of redox glutathione levels and gene transcription in lung inflammation therapeutic approaches. Free Radic. Biol. Med. 28 1405-1420. 

Taken together these experimental and clinical observations support the hypothesis that there is no gut inflammation without bacteria, and that the manipulation of enteric microflora may represent a possible therapeutic approach in IBD. 

Yusuf-Makagiansar H, Anderson ME, Yakovleva TV, et al. Inhibition of LFA-1/ ICAM-1 and VLA-4/VCAM-1 as a therapeutic approach to inflammation and autoimmune diseases. Med Res Rev 2002 22 146-67. 

The accumulation of evidence implicating a role for adenosine in the pathogenesis of airway inflammation has led to investigations into all adenosine receptor subtypes as potential therapeutic targets for the treatment of asthma and COPD. To this end, the efficacy of A3AR in the clinical setting has been inconclusive. However, inhibition of Aj and A2B receptors and/or activation of the A2A pathway may serve as an alternative therapeutic approach (Brown et al. 2008b). 

Selectin-dependent adhesion inhibitors offer a new therapeutical approach to the prevention of transplant rejection. They should also enable treatment and prophylaxis of various other pathological inflammation processes and diseases (i.e. rheumatic arthritis, dermatitis and bacterial meningitis) initiated by a massive invasion of leucocytes [1,7]. 

Klaidman, L.K., Adams, J.D., Jr., Cross, R., Pazdemik, T.L., Samson, F. (2003). Alterations in brain glutathione homeostasis induced by the nerve gas soman. Neurotox. Res. 5 177-82. Klegeris, A., McGeer, E.G., McGeer, P.L. (2007). Therapeutic approaches to inflammation in neurodegenerative disease. Curr. Opin. Neurol. 20 351-7. 

Hussain I, Kline JN. CpG oligodeoxynucleotides A novel therapeutic approach for atopic disorders. Curr Drug Targets Inflamm Allergy. 2003 2 199-205. 

Therefore, inhibition of anandamide amidohydrolase to increase the accumulation of anandamide at its sites of action is desirable as a potential therapeutic approach for the treatment or prevention of disorders such as mental diseases, inflammation and pain, including treatment or prevention of schizophrenia, mood disorders, anorexia, multiple sclerosis, spasticity and glaucoma. Source Piomelli 1999... 

With the role of S. aureus as disease modifier being established, a number of therapeutic approaches may be considered (fig. 2). The potential therapeutic effect of a treatment to eradicate S. aureus in polyp disease or asthma has not been studied yet, but large-scale double-blind placebo-controlled randomized studies are currently ongoing. From atopic dermatitis, a disease sharing the modifying effects of staphylococcal superantigens on inflammation and disease severity, we can deduce therapeutic approaches. The skin of up to 100% of patients with atopic dermatitis is colonized with S. aureus, of which up to 65% have been shown to produce enterotoxins with superantigenic properties. Ten patients were treated orally with antibiotics, chlorhexidine ointment was... 

MeInnes IB, Leung BP, Harnett M et al. A novel therapeutic approach targeting articular inflammation using the filarial nematode-derived phosphorylcholine-containing glycoprotein ES-62. J Immunol 2003 171(4) 2127-2133. 

Akiyama, H., Barger, S., Bamum, S., et al. Inflammation and Alzheimer s disease. Neurobiol. Aging (2000). doi 10.1016/S0197-I580(00)00124-X Morales, L, Guzman-Martinez, L., Cerda-Troncoso, C., et al. Nenroinflammation in the pathogenesis of Alzheimer s disease. A rational framework for the search of novel therapeutic approaches. Front. Cell. Nenrosci. 8, 112 (2014). 

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