Infiltration Lipopolysaccharide

CD28, a costimulatory molecule for T cell activation. CD 28 deficient mice Lipopolysaccharide lOpg/g IP Yes. LessTcell infiltration in kidney [207]... 

Kupffer cells are major targets for lipopolysac-charides. Hepatic macrophages engulf lipopolysac-charide by phagocytosis (Mathison and Ul-EviTCH 1979). Lipopolysaccharide increased Oj " production in Kupffer cells (Bautista et al. 1990). Additionally, Upopolysaccharide induces migration of activated polymorphonuclear neutrophils into the Uver (Levy et al. 1967). Since these cells are the other source of free radicals, the intensity of polymorphonuclear neutrophil infiltration determines the degree of hepatic endotoxemia (Hewett et al. 1992). 

Obesity is associated with a state of chronic, low-grade systemic inflammation. The adipocytes themselves, as well as the infiltrated macrophages in the adipose tissue in an obese state, express inflammatory cytokines. This low-grade systemic inflammation is caused, at least in part, by translocation of bacterial lipopolysaccharide... 

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