Infectious diseases chemokines associated with

Chemokines Associated with Infectious Diseases in Human and Animal Models... 

In this chapter we will investigate the putative role for chemokines in RRV disease, and will focus particularly on the polyarthritis often associated with RRV infection. Here we will address the precise role and activity of chemokines in EPA. This chapter will also draw on studies from other infectious and noninfectious arthritic syndromes in an attempt to understand the possible chemokine basis of RRV pathogenesis and EPA. 

Temporal studies have shown that particular cytokines and chemokines are associated with acute or chronic phases of RA, while RRV studies in animals have shown that after severe macrophage associated muscle necrosis post infection, tissue recovery could be observed with a return to normal function, which correlated with the disappearance of monocyte/macrophages from the site of pathology. Therefore, as well as elucidating the role for chemokines in the disease phase of EPA and other infectious arthritidies, future challenges will also center on the function of chemokines and collaborating cytokines in the recovery from arthritic/myalgic disease post infection. 

---