Induced learning impairments

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Chronic nicotine treatment reverses hypothyroidism-induced impairment of hippocampal learning and short-term memory [21]. It also prevents hypothyroidism-induced impairment of E-LTP and facilitation of LTD in area CAl [21,22]. At the molecular level, nicotine normalizes the reduction of basal activity of CaMKII and levels of P-CaMKII in area CAl [22]. One hour after the induction of E-LTP in CAl, the failure of HFS to increase the levels of P-CaMKII in hypothyroidism is reversed by chronic nicotine pretreatment, suggesting that nicotine by restoring the ability of HFS to activate CaMKII and by normalizing the basal activity and levels of CaMKn reverses hypothyroidism-induced LTP impairment [22]. In addition, chronic nicotine treatment prevents hypothyroidism-induced reduction in protein levels of molecules upstream to CaMKII such as PKCy, neurogranin, and calmodulin [22]. 

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