Indoor plasticizers and health

4 IMPACT OF PLASTICIZERS IN THE INDOOR ENVIRONMENT 17.5.4.1 Indoor Plasticizers and Health [Pg.579]

Aeute toxicity of all phthalates is low. Subacute and chronic effects of phthalates were summarized by Lorz et alP They depend on chain length and stmeture of the aleo-hol moiety. Thrrs, a differerrtiation between short-, mediirm- and long-chain esters seertts neeessaiy. After errtering the human organism, one of the two ester bonds of phthalates is cleaved and the aleohol is released. Toxicological effects may resirlt from the phthalie add monoester and its sequel produets and/or from the alcohol. [Pg.579]

Medirrm-chain phthalate esters (DBP, DiBP, DCHP) exhibit degenerative testicular effects upon repeated oral adrtrirtistration in all species investigated. Furthermore, in [Pg.579]

Health and Safety Issues with Plasticizers and Plasticized Materials [Pg.580]

DEHP is the long-chain phthalate ester examined most extensively, and hundreds of publications on toxicological profile, biochemistry, and metabolism exist. Far fewer data have been generated on other phthalates of this group. Branched-chain phthalates commonly share a potential to induce peroxisomes and hepatomegaly in livers of rats and mice at high doses. [Pg.580]

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