Indomethacin physicochemical properties

Guterres SS, Weiss V, de Lucca Freitas L, Pohlmann AR. Influence of benzyl benzoate as oil core on the physicochemical properties of spray-dried powders from polymeric nanocapsules containing indomethacin. Drug Deliv 2000 7(4) 195—199. 

Lim RTY, Ng WK, Widjaja E, Tan RBH (2013) Comparison of the physical stability and physicochemical properties of amorphous indomethacin prepared by co-milling and supercritical anti-solvent co-precipitation. J Supercr Fluids... 

Lobmann et al. (2011) prepared co-amorphous binary blends of the two BCS class 2 drugs indomethacin and naproxen with the main aim to further investigate the type of molecular interactions in co-amorphous blends and their influence on recrystallization, dissolution and physicochemical properties. They were able to successfully produce co-amorphous blends at the molar ratios 2 1, 1 1, and 1 2 using quench cooling. Similar to the results obtained by Allespet al. (2009), naproxen showed poor physical stability in its pure amorphous form. However, in combination with indomethacin, stable co-amorphous single-phase systems could be obtained. 

Corrigan OI, Holohan EM, Reilly MR. Physicochemical properties of indomethacin and related compounds co-spray dried with polyvinyl-pyrrolidone. Drug Dev Ind Pharm... 

Eihei F, Makita M, Yamamura S. Some physicochemical properties of glassy indomethacin. Chem Pharm Bull 1986 37 4314-4321. 

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