Indomethacin gel

Jn drug stability studies, the rates of hydrolysis of indomethacin (Sigma-Chem.) were considerably slower in Pluronic F 127 (BASF) gels than in buffer alone. The degradation of indomethacin followed 1st order kinetics, with linear plots of the 1st order rate constant vs. pH in both Pluronic and aqueous solutions, allowing prediction of the time required for degradation of indomethacin."... 

Fig. 1. Pulsatile release rate of indomethacin from poly(IPAAm-co-BMA) gel (BMA 5 wt %) in response to stepwise temperature changes between 10°C and 30°C...

Oral ibuprofen is often prescribed in lower doses (< 2400 mg/d), at which it has analgesic but not anti-inflammatory efficacy. It is available over the counter in low-dose forms under several trade names. A topical cream preparation appears to be absorbed into fascia and muscle an (S)( ) formulation has been tested. Ibuprofen cream was more effective than placebo cream for the treatment of primary knee osteoarthritis. A liquid gel preparation of ibuprofen 400 mg provided faster relief and superior overall efficacy in postsurgical dental pain. In comparison with indomethacin, ibuprofen decreases urine output less and also causes less fluid retention than indomethacin. Ibuprofen has been shown to be effective in closing patent ductus arteriosus in preterm infants, with much the same efficacy and safety as indomethacin. Oral ibuprofen is as effective as intravenous administration in this condition. 

Sondergaard and Steines measured indomethacin in plasma and urine by direct quantitative TLC using chloroform-methanol(30 6) on silica gel(47). Reliable quantitation was achieved at the 30 ng/ml level(+12%). 

Allessandro and co-workers using silica gel G were able to separate indomethacin from drugs of similar pharmacological properties(40). Likewise Thompson and Johnson reported values for a variety of analgesics, antipyretics and anti-inflammatory drugs which were separable from indomethacin(48). Polyamide gels were also used by Hsiu et al. to resolve a series of antipyretics including indomethacin(49). 

Several studies have reported on the enhanced bioavailability of cutaneous drugs using o/w and w/o MEs compared to conventional emulsions, gels or solutions, mesophases, micellar and inverse micellar systems, and vesicles [93], Moreover, a diverse range of drug molecules such as ketoprofen, apomorphine, estradiol, lido-caine [94-97], indomethacin and diclofenac [98], prostaglandin Ei [99], aceclofenac... 

Alkaline hydrolysis of forskolin is inhibited in a lipid emulsion.550 Indomethacin in an oil-water gel is solubilized in the surfactant aggregates and stabilized against acid- and base-catalyzed hydrolysis.551... 

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