Indomethacin-copper complex

The list of compounds presented in Table 6.4 includes copper complexes of well-known antiarthritic drugs, including salicylic acid, aspirin, diflunisal, niflumic acid, D-penicillamine, hydrocortisone, dexamethasone, dimethyl-sul-phoxide, clopirac, ketoprofen, ibuprofen, (+ )-naproxen, indomethacin, me-fenamic acid, thiomalic acid, phenylbutazone, lonazolac, isoxicam and azo-propazone. While there has been much discussion concerning the qualitative and quantitative activities of these complexes [136, 152-156, 164, 187], it is... 

More recent studies have clearly shown that Cu(II)(anthranilate)2, Cu(II)(salicylate)2, Cu(II)2(3,5-DIPS)4, Cu(II)2(aspirinate)4, Cu(II)2(niflu-mate)4, and Cu(II)2(indomethacin)4 are more effective analgesics than their parent ligands [93]. As shown in Table 6.5, copper complexes of salicylic acid,... 

DIPS, aspirin, niflumic acid and indomethacin were more effective than their parent compounds and CUCI2 or Cu2(acetate)4 in writhing and polyarth-ritic pain models. In addition, the copper complex of indomethacin was found to be as effective as morphine in both pain models and the amount of copper... 

The antiinflammatory drugs indomethacine (l-(p-chlorobenzoyl)-5-methoxy-2-methyl-indole acetate) and lonazolac (3-p-chlorophenyl)-l-phenyl-pyrazole-4-acetate) form thermodynamically stable copper complexes in aprotic solutions, which are highly superoxide dismutase active An example for the structure of these... 

Surprisingly, in such complexes, the copper-copper distance (263 pm) is very close to that of metallic copper A spin-spin interaction, namely an antiferromagnetic coupling of the copper is observed. Two coordination sites in the copper-copper axis can be readily replaced by superoxide. For Cu2(indomethacin)4 a second-order rate... 

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