Indole 5-chloro-2-phenyl

The Reimer-Tiemann reaction has also been used to formylate 2,5-dimethylpyrrole and its iV-methyl derivative and indoles having methyl, methoxyl, and phenyl substituents. Significantly, 3-methylindole gave only 3-chloro-4-methylquinoline. ... 

As with the pyrroles, N-chloroamides have been widely employed in indole chlorination [66JOC2627 80H( 14)867 81JOC2054]. Chloroindolen-ines may be isolated under controlled conditions [80H( 14)867 81JOC2054], 2-Phenyl-, l-methyl-2-phenyl-and 3-methyl-2-phenyl-indoles were converted by 1-chloroisatin (NCI) into the 3-chloro derivatives... 

Recently, SB-269970 (l-[3-hydroxy-phenyl-sulphonyl]-2-[2-(4-methyl-l-piperidinyl)-ethyl] pyrrolidine) and SB-656104 (6-((R)-2- 2-[4-(4-chloro-phenoxy)-piperidin-l-yl]-ethyl pyrrolidine-l-sulphonyl)-lH-indole) have been reported to be potent 5-HT7 receptor antagonists (Hagan et al., 2000 Forbes et al., 2002). Selective 5-HT7 receptor agonists are not available at the present time. Systemic administration of SB-269970 or SB-656104 to rats at the beginning of the light period has been shown to reduce the total amount of REMS and to increase REMS latency. Values of W and SWS were not significantly modified (Hagan et al., 2000 Thomas et al., 2003). Hedlund et al. (2005) established that 5-HT7... 

Some other ring expansions involving the intramolecular amino Claisen rearrangement of vinylarylaziridine [ 123], the Diels-Alder reaction of indoles with acetylene derivative [124-127] and the dibromocarbene insertion into quinoline enol ethers [ 128] have been used to prepare 1-benzazepines. On the other hand, treatment of 3-chloro-3-phenyl-l,2,3,4,5,6-hexahydro-l-benz-azocin-2-ones with piperidine causes a ring contraction to give 2-phenyl-2-(l-piperidinylcarbonyl)-2,3,4,5-tetrahydro-l//-l-bcnzazepines in an excellent yield [23]. 

Jbenzopyrano- [4,3-b] -1,4-oxazin-9-ol (S)-2-(6-chloro-5-fluoro-indol-l-yl)-l-methylethylamine (R)-(+)-8-chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-lH-3-benzazepine-7-ol... 

Chloro-l-(4-fluoro-phcnyl)-4-oxo- -5-fluoro-2-oxo- EI6b. 406 (subst. Indol t snbsl. Ketenimin) 3-Chloro-4-oxo-l-phenyl- -5(or 6)-fluoro-2-oxo- EI6b, 406 (Indol-Der. + subst. Ketenimin) 3-Chloro-4-oxo-l-(4-trifluoromethyl-phenyl)- -5(or 6)-fluoro-2-oxo-EI6b. 406 (Indol-Der, + subst. Ketenimin)... 

The four target molecules are indole [(63), R1 = R2 = H], 5-chloro-2-phenyl-... 

Ml - INDOLE, 5-CHLORO-3-METHYL-2-(p-l2-11-PYRROLIDINYL)ETH0XY)PHENYL)-... 

A Suzuki coupling of 5-chloro-2-methyl-6-phenyl-2H-pyridazin-3-one (10) ultimately led to diazino-fused indole 11 and cinnoline 12 and allowed access to a novel pyrimidoisoquinoline ring system in a one-pot fashion <02T10137>. Mn(II)-azido networks of the type [Mn(N3)2(L)] like 13 with new 3-D topologies were obtained using both pyridazine and pyrimidine ligands <02CC64>. 

The 3-azido-3/f-indoles 3 undergo thermal rearrangement, upon refluxing in dimethylformamide, giving variable yields and ratios of quinazolines 4 and quinoxalines 5, along with the formation of the parent indoles 6. Thus, heating of 3-azido-5-chloro-3-methyl-2-phenyl-3//-indolc for 16 hours in dimethylformamide affords 6-chloro-4-methyl-2-phenylquinazoline (30%), 6-chloro-3-methyl-2-phenylquinoxaline (20%), and a trace of 5-chloro-3-methyl-2-phenyl-l//-indole. ... 

A highly flexible catalytic one-pot procedure for the synthesis of indoles employing or/ o-chloro-substituted l-phenyl-2-alkyl-alkynes or phenyl(aminoalkyl)alkynes as starting materials through a reaction catalyzed by Cp2TiMe2 has been reported.1916... 

ETHYL 5-CHLORO-3-PHENYLINDOLE-2-CARBOXYLATE 1H-INDOLE-2-CARBOXYLIC ACID, 5-CHLORO-3-PHENYL-, ETHYL ESTER ... 

In the zinc-calcium formulations, metal soaps are associated with secondary stabilizers such as alkylphosphites, epoxy compounds, a-phenyl-indole, or -aminocrotonate esters that bring a synergistic effect. The first attempt to study the mechanisms behind this effect has been the reaction of all of these compounds with 4-chloro-2-hexene. 

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