Alkynes aminoalkylation

A highly flexible catalytic one-pot procedure for the synthesis of indoles employing or/ o-chloro-substituted l-phenyl-2-alkyl-alkynes or phenyl(aminoalkyl)alkynes as starting materials through a reaction catalyzed by Cp2TiMe2 has been reported.1916... 

The insertion approach is very successful in the hydroamination of alkynes and alkenes catalyzed by lanthanide complexes developed by Marks et al. [220]. Thorough mechanistic studies have been undertaken for the intramolecular reaction (hydroamination-cyclization of aminoalkenes), although the intermolecular version of the process is also efficient [222]. The mechanism of the reaction can be represented in a simplified way by Scheme 6.68. The insertion step is almost thermoneutral, but the protonolysis of the M-aminoalkyl bond that follows is exothermic and provides the necessary driving force. The insertion of the alkene into the Ln-N bond is irreversible and rate determining and it goes through a... 

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