Voriconazole Indinavir

Azalides azithromycin Azoles fluconazole, itraconazole, ketoconazole, and voriconazole Macrolides erythromycin, clarithromycin Protease inhibitors amprenavir, indinavir, lopinavir/ritonavir, nelfinavir, ritonavir, and saquinavir Quinolones ciprofloxacin, gatifloxacin, levofloxacin, moxifloxacin. 

Drugs that may be affected by atazanavir include the following antiarrhythmics, atenolol, benzodiazepines, calcium channel blockers, cisapride, clarithromycin, ergot derivatives, HMG-CoA reductase inhibitors, immunosuppressants, indinavir, irinotecan, itraconazole, ketoconazole, oral contraceptives, PDE5 inhibitors, pimozide, rifabutin, saquinavir, tenofovir, tricyclic antidepressants, voriconazole, warfarin. 

Drugs that may affect atazanavir include the following antacids and buffered medications, clarithromycin, didanosine (buffered formulation only), efavirenz, H2-receptor antagonists, indinavir, itraconazole, ketoconazole, nevirapine, proton pump inhibitors, rifampin, ritonavir, St. John s wort, tenofovir, voriconazole. 

Others Acetaminophen, amiodarone, carbamazepine, delavirdine, efavirenz, nevirapine, quinidine, repaglinide, sildenafil, tadalafil, trazodone, vardenafil Amiodarone, amprenavir, atazanavir, ciprofloxacin, cisapride, clarithromycin, diltiozem, erythromycin, fluconazole, fluvoxamine, grapefruit juice (in high ingestion), indinavir, itraconazole, ketoconazole, nefazodone, nelfinavir, norfloxacin, ritonavir, telithromycin, troleandomycin, verapamil, voriconazole Carbamazepine, efavirenz, glucocorticoids, macrolide antibiotics, nevirapine, phenytoin, phenobarbital, rifabutin, rifapentine, rifampin, St. John s wort... 

Drugs that may inhibit cytochrome P450 metabolism of other drugs include amiodarone, androgens, atazanavir, chloramphenicol, cimetidine, ciprofloxacin, clarithromycin, cyclosporine, delavirdine, diltiazem, diphenhydramine, disulfiram, enoxacin, erythromycin, fluconazole, fluoxetine, fluvoxamine, furanocoumarins (substances in grapefruit juice), indinavir, isoniazid, itraconazole, ketoconazole, metronidazole, mexile-tine, miconazole, nefazodone, omeprazole, paroxetine, propoxyphene, quinidine, ritonavir, sulfamethizole, verapamil, voriconazole, zafirlukast, and zileuton. 

Clinically important, potentially hazardous interactions with amiodarone, azithromycin, bepredil, bosentan, bretylium, cisapride, clarithromycin, disopyramide, erythromycin, erythromycin fluconazole, fluoxetine, fluvoxamine, grapefruit juice, indinavir, itraconazole, ketoconazole, metronidazole, miconazole, nefazodone, nilotinib, paroxetine, pimozide, probucol, procainamide, quinidine, quinine, ritonavir, saquinavir, sertraline, sotalol, SSRIs, terfenadine, troleandomycin, voriconazole, zileuton, ziprasidone... 

Clinically important, potentially hazardous interactions with amprenavir, atazanavir, clarithromycin, delavirdine, grapefruit juice, indinavir, itraconazole, ketoconazole, nefazodone, ritonavir, saquinavir, telithromycin, voriconazole... 

The AUC of erlotinib has been found to be increased by 66% when given with ketoconazole 200 mg twice daily for 5 days. The manufacturers advise caution with concurrent use, and recommend that the dose of erlotinib should be reduced if severe adverse reactions occur when given with strong CYP3A4 inhibitors. They specifically name atazanavir, clarithromycin, erythromycin, grapefruit and grapefruit juice, indinavir, itraconazole, ketoconazole, nefazodone, neltinavir, ritonavir, saquinavir, telithromycin, troleandomycin and voriconazole. ... 

The current use of protease inhibitors and voriconazole is predicted to interfere with the metabolism of both drugs. Studies suggest that ritonavir decreases voriconazole levels, but no interaction was seen between indinavir and voriconazole in one study. 

In a study in 18 healthy subjects, the pharmacokinetics of hoth indinavir 800 mg three times daily and voriconazole 200 mg twice daily were unaffected hy at least a week of concurrent use. However, in vitro studies suggest that the metaholism of HfV-protease inhihitors may he inhihited hy voriconazole, and the metaholism of voriconazole may he inhihited hy HTV-protease inhibitors. The manufacturer therefore suggests that patients should be carefully monitored for evidence of drug toxicity and/or loss of efficacy during concurrent use of other HIV-protease inhibitors (amprenavir, neliinavir and saquinavir are specifically mentioned). ... 

The manufacturers of voriconazole say that the concurrent use of ritonavir (at doses of400 mg and above twice daily) is contraindicated, presumably because the efficacy of the voriconazole is expected to be markedly reduced. The manufacturer of ritonavir also recommends that when it is used as a pharmacokinetic enhancer (usually 100 mg twice daily) voriconazole should only be given if the benefits outweigh the risks. Most protease inhibitors are given with ritonavir as a pharmacokinetic enhancer however, caution is also warranted if they are given alone, as all the protease inhibitors can inhibit CYP3A4 to some extent and may therefore also increase voriconazole levels. Voriconazole may also affect protease inhibitor levels, but other than ritonavir and indinavir, which are not affected this does not appear to have been studied. Be aware that some increase in their levels is theoretically possible if voriconazole is given. 

Puikiiis L, WoodN, Kleinermans D, Love ER. No clinically significant pharmacokinetic interactions between voriconazole and indinavir in healthy volunteeiB. BrJ Clin Pharmacol (2003) 56(Suppll),62-8. 

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